Items where Author is "Le Brun, Nick"

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Li, Chun-Yang, Crack, Jason C., Newton-Payne, Simone, Murphy, Andrew R. J., Chen, Xiu-Lan, Pinchbeck, Benjamin J., Zhou, Shun, Williams, Beth T., Peng, Ming, Zhang, Xiao-Hua, Chen, Yin, Le Brun, Nick E., Todd, Jonathan D. and Zhang, Yu-Zhong (2022) Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB. mLife, 1 (2). pp. 114-130. ISSN 2770-100X

Peng, Ming, Li, Chun-Yang, Chen, Xiu-Lan, Williams, Beth, Kang, Li, Gao, Ya-Nan, Wang, Peng, Wang, Ning, Gao, Chao, Zhang, Shan, Schoelmerich, Marie C., Banfield, Jillian F., Miller, J. Benjamin, Le Brun, Nick E., Todd, Jonathan D. and Zhang, Yu-Zhong (2022) Insights into methionine S-methylation in diverse organisms. Nature Communications, 13. ISSN 2041-1723

Yeh, Chieh-Chih George, Mokkawes, Thirakorn, Bradley, Justin, Le Brun, Nick E. and de Visser, Sam (2022) Second coordination sphere effects on the mechanistic pathways for dioxygen activation by a ferritin: involvement of a Tyr radical and the identification of a cation binding site. ChemBioChem. ISSN 1439-4227

Crack, Jason C., Balasiny, Basema K., Bennett, Sophie P., Rolfe, Matthew D., Froes, Afonso, MacMillan, Fraser, Green, Jeffrey, Cole, Jeffrey A. and Le Brun, Nick E. (2022) The di-iron protein YtfE is a nitric oxide-generating nitrite reductase involved in management of nitrosative stress. Journal of the American Chemical Society, 144 (16). 7129–7145. ISSN 0002-7863

Sims, Leanne P., Lockwood, Colin W. J., Crombie, Andrew T., Bradley, Justin M., Le Brun, Nick E. and Murrell, J. Colin (2022) Purification and characterization of the isoprene monooxygenase from Rhodococcus sp. strain AD45. Applied and Environmental Microbiology, 88 (7). ISSN 0099-2240

Honarmand Ebrahimi, Kourosh, Ciofi-Baffoni, Simone, Hagedoorn, Peter-Leon, Nicolet, Yvain, Le Brun, Nick E., Hagen, Wilfred R. and Armstrong, Fraser A. (2022) Iron–sulfur clusters as inhibitors and catalysts of viral replication. Nature Chemistry, 14 (3). 253–266. ISSN 1755-4330

Crack, Jason and Le Brun, Nick (2021) Biological iron-sulfur clusters: mechanistic insights from mass spectrometry. Coordination Chemistry Reviews, 448. ISSN 0010-8545

Bradley, Justin M., Fair, Josh, Hemmings, Andrew M. and Le Brun, Nick E. (2021) Key carboxylate residues for iron transit through the prokaryotic ferritin SynFtn. Microbiology, 167 (11). ISSN 1350-0872

Crack, Jason C. and Le Brun, Nick E. (2021) Native Mass Spectrometry of Iron-Sulfur Proteins. In: Methods in Molecular Biology. Methods in Molecular Biology. ISBN 978-1-0716-1605-5_13

Crack, Jason C., Gray, Elizabeth and Le Brun, Nick E. (2021) Sensing mechanisms of iron–sulfur cluster regulatory proteins elucidated using native mass spectrometry. Dalton Transactions, 50 (23). pp. 7887-7897. ISSN 1477-9226

Pullin, Jacob, Bradley, Justin M., Moore, Geoffrey R., Le Brun, Nick E., Wilson, Michael T. and Svistunenko, Dimitri A. (2021) Electron transfer from haem to the di-iron ferroxidase centre in bacterioferritin. Angewandte Chemie International Edition, 60 (15). pp. 8376-8379. ISSN 1433-7851

Pullin, Jacob, Wilson, Michael T., Clémancey, Martin, Blondin, Geneviève, Bradley, Justin M., Moore, Geoffrey R., Le Brun, Nick E., Lučić, Marina, Worrall, Jonathan A. R. and Svistunenko, Dimitri A. (2021) Iron oxidation in Escherichia coli bacterioferritin ferroxidase centre, a site designed to react rapidly with H2O2 but slowly with O2. Angewandte Chemie International Edition, 60 (15). pp. 8361-8369. ISSN 1433-7851

Bradley, Justin M., Svistunenko, Dimitri A., Wilson, Michael T., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E (2020) Bacterial iron detoxification at the molecular level. The Journal of Biological Chemistry, 295 (51). pp. 17602-17623. ISSN 0021-9258

Bennett, Sophie, Torres, Maria, Soriano-Laguna, Manuel, Richardson, David, Gates, Andrew J and Le Brun, Nick (2020) nosX is essential for whole cell N2O reduction in Paracoccus denitrificans but not for assembly of copper centres of nitrous oxide reductase. Microbiology, 166 (10). 909–917. ISSN 1350-0872

Stewart, Melissa, Bush, Matthew, Crack, Jason, Buttner, Mark and Le Brun, Nick (2020) Interaction of the Streptomyces Wbl protein WhiD with the principal sigma factor σHrdB depends on the WhiD [4Fe-4S] cluster. Journal of Biological Chemistry, 295 (28). pp. 9752-9765. ISSN 0021-9258

Volbeda, Anne, Crack, Jason, Le Brun, Nick and Fontecilla-Camps, Juan C. (2020) Structure-function relationships of the NsrR and RsrR transcription regulators. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. John Wiley and Sons Ltd. (In Press)

Crack, Jason C., Amara, Patricia, Volbeda, Anne, Mouesca, Jean-Marie, Rohac, Roman, Pellicer Martinez, Maria, Huang, Chia-Ying, Gigarel, Océane, Rinaldi, Clara, Le Brun, Nick E. and Fontecilla-Camps, Juan C. (2020) Electron and proton transfers modulate DNA binding by the transcription regulator RsrR. Journal of the American Chemical Society, 142 (11). pp. 5104-5116. ISSN 0002-7863

Bradley, Justin, Pullin, Jacob, Moore, Geoff, Svistunenko, Dimitri A., Hemmings, Andrew and Le Brun, Nick (2020) Routes of iron entry into, and exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn. Dalton Transactions, 49 (5). pp. 1545-1554. ISSN 1477-9226

Pellicer Martinez, Maria Teresa, Crack, Jason, Stewart, Melissa, Bradley, Justin, Svistunenko, Dimitri A., Johnston, Andrew, Cheesman, Myles, Todd, Jonathan and Le Brun, Nick (2019) Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA. eLife, 8. ISSN 2050-084X

Bennett, Sophie, Soriano-Laguna, Manuel, Bradley, Justin, Svistunenko, Dimitri A., Richardson, David, Gates, Andrew and Le Brun, Nicolas (2019) NosL is a dedicated copper chaperone for assembly of the Cuz center of nitrous oxide reductase. Chemical Science, 10 (19). pp. 4985-4993. ISSN 2041-6520

Crack, Jason C. and Le Brun, Nicolas (2019) Mass spectrometric identification of [4Fe-4S](NO)x intermediates of nitric oxide sensing by regulatory iron-sulfur cluster proteins. Chemistry - A European Journal, 25 (14). pp. 3675-3684. ISSN 0947-6539

Volbeda, Anne, Pellicer Martinez, Ma Teresa, Crack, Jason C., Amara, Patricia, Gigarel, Océane, Munnoch, John T., Hutchings, Matthew I., Darnault, Claudine, Le Brun, Nick E. and Fontecilla-Camps, Juan C. (2019) Crystal structure of the transcription regulator RsrR reveals a [2Fe-2S] cluster coordinated by Cys, Glu and His residues. Journal of the American Chemical Society, 141 (6). 2367–2375. ISSN 0002-7863

Bradley, Justin M., Svistunenko, Dimitri A., Pullin, Jacob, Hill, Natalie, Stuart, Rhona K., Palenik, Brian, Wilson, Michael T., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E. (2019) Reaction of O2 with a di-iron protein generates a mixed valent Fe2+/Fe3+ center and peroxide. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 116 (6). pp. 2058-2067. ISSN 1091-6490

Crack, Jason, Stewart, Melissa and Le Brun, Nicolas (2019) Generation of 34S-substituted protein-bound [4Fe-4S] clusters using 34S-L-cysteine. Biology Methods and Protocols, 4 (1). ISSN 2396-8923

Kay, Kristine L., Hamilton, Chris J. and Le Brun, Nick E. (2019) Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol. Journal of Inorganic Biochemistry, 190. pp. 24-30. ISSN 0162-0134

Child, Stella A., Bradley, Justin M., Pukala, Tara L., Svistunenko, Dimitri A., Le Brun, Nick E. and Bell, Stephen G. (2018) Electron transfer ferredoxins with unusual cluster binding motifs support secondary metabolism in many bacteria. Chemical Science, 9 (41). pp. 7948-7957. ISSN 2041-6520

Crack, Jason C. and Le Brun, Nick E. (2018) Redox-sensing iron–sulfur cluster regulators. Antioxidants & Redox Signaling, 29 (18). pp. 1809-1829. ISSN 1523-0864

Crack, Jason C., Hamilton, Chris J. and Le Brun, Nick E. (2018) Mass spectrometric detection of iron nitrosyls, sulfide oxidation and mycothiolation during nitrosylation of the NO sensor [4Fe-4S] NsrR. Chemical Communications, 54 (47). pp. 5992-5995. ISSN 1359-7345

Adinolfi, Salvatore, Puglisi, Rita, Crack, Jason, Iannuzzi, Clara, Dal Piaz, Fabrizio, Konarev, Petr V., Svergun, Dmitri I., Martin, Stephen, Le Brun, Nick E. and Pastore, Annalise (2018) The molecular bases of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX. Frontiers in Molecular Biosciences, 4. ISSN 2296-889X

Zhou, Liang, Kay, Kristine L., Hecht, Oliver, Moore, Geoffrey R. and Le Brun, Nick E. (2018) The N-terminal domains of Bacillus subtilis CopA do not form a stable complex in the absence of their inter-domain linker. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1866 (2). pp. 275-282.

Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P. and Green, Jeffrey (2017) Structure of a Wbl protein and implications for NO sensing by M. tuberculosis. Nature Communications, 8. ISSN 2041-1723

Crack, Jason C. and Le Brun, Nick E. (2017) Iron–Sulfur Cluster-based Sensors. In: Gas Sensing in Cells. Metallobiology. RSC Publishing, pp. 136-178. ISBN 978-1-78262-895-8

Bradley, Justin M., Svistunenko, Dimitri A., Moore, Geoffrey R. and Le Brun, Nick E. (2017) Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre. Metallomics, 9 (10). pp. 1421-1428. ISSN 1756-5901

Dodd, Erin L., Crack, Jason C., Thomson, Andrew J. and Le Brun, Nick E. (2017) Reactivity of iron-sulfur clusters with nitric oxide. In: Iron-Sulfur Clusters in Chemistry and Biology. De Gruyter, pp. 387-438. ISBN 978-3-11-048043-6

Smith, Laura J., Bochkareva, Aleksandra, Rolfe, Matthew D., Hunt, Debbie M, Kahramanoglou, Christina, Braun, Yvonne, Rodgers, Angela, Blockley, Alix, Coade, Stephen, Lougheed, Kathryn EA, Hafneh, Nor Azian, Glenn, Sarah M, Crack, Jason C, Le Brun, Nick E, Saldanha, José W, Macarov, Vadim, Nobeli, Irene, Arnvig, Kristine, Mukamolova, Galina V, Buxton, Roger S and Green, Jeffrey (2017) Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence. Nucleic Acids Research, 45 (11). pp. 6600-6612. ISSN 0305-1048

Volbeda, Anne, Dodd, Erin L., Darnault, Claudine, Crack, Jason C., Renoux, Oriane, Hutchings, Matthew I., Le Brun, Nick E. and Fontecilla-Camps, Juan C. (2017) Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nature Communications, 8. ISSN 2041-1723

Crack, Jason C., Thomson, Andrew J. and Le Brun, Nick E. (2017) Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114 (6). E3215–E3223. ISSN 1091-6490

Bradley, Justin M., Moore, Geoffrey R. and Le Brun, Nick E. (2017) Diversity of Fe2+ entry and oxidation in ferritins. Current Opinion in Chemical Biology, 37. 122–128. ISSN 1367-5931

Bastow, Emma L., Bych, Katrine, Crack, Jason C., Le Brun, Nick E. and Balk, Janneke (2017) NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulfur proteins in Arabidopsis thaliana. The Plant Journal, 89 (3). 590–600. ISSN 0960-7412

Kay, Kristine L., Zhou, Liang, Tenori, Leonardo, Bradley, Justin Michael, Singleton, Chloe, Kihlken, Margaret A., Ciofi-Baffoni, Simone and Le Brun, Nicolas (2017) Kinetic analysis of copper transfer from a chaperone to its target protein mediated by complex formation. Chemical Communications, 53 (8). pp. 1397-1400. ISSN 1359-7345

Pellicer Martinez, Maria, Bermejo Martinez, Ana, Crack, Jason, Holmes, John D., Svistunenko, Dimitri, Johnston, Andrew, Cheesman, Myles, Todd, Jonathan and Le Brun, Nick (2017) Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA. Chemical Science, 8. pp. 8451-8463. ISSN 2041-6520

Serrano, Pauline N., Wang, Hongxin, Crack, Jason C., Prior, Christopher, Hutchings, Matthew I., Thomson, Andrew J., Kamali, Saeed, Yoda, Yoshitaka, Zhao, Jiyong, Hu, Michael Y., Alp, Ercan E., Oganesyan, Vasily S., Le Brun, Nick E. and Cramer, Stephen P. (2016) Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes. Angewandte Chemie International Edition, 55 (47). 14575–14579. ISSN 1433-7851

Munnoch, John T., Pellicer Martinez, Ma Teresa, Svistunenko, Dimitri A., Crack, Jason C., Le Brun, Nick E. and Hutchings, Matthew I. (2016) Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily. Scientific Reports, 6. ISSN 2045-2322

Kay, Kristine L., Hamilton, Chris J. and Le Brun, Nick E. (2016) Mass spectrometry of B. subtilis CopZ: Cu(I)-binding and interactions with bacillithiol. Metallomics, 8 (7). pp. 709-719. ISSN 1756-591X

Crack, Jason, Svistunenko, Dimitri A., Munnoch, John, Thomson, Andrew, Hutchings, Matthew and Le Brun, Nicolas (2016) Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA-binding to reaction with nitric oxide. Journal of Biological Chemistry, 291. pp. 8663-8672. ISSN 0021-9258

Bradley, Justin, Le Brun, Nick and Moore, Geoffrey (2016) Ferritins: furnishing proteins with iron. JBIC Journal of Biological Inorganic Chemistry, 21 (1). pp. 13-28. ISSN 0949-8257

Crack, Jason, Hutchings, Matthew, Thomson, Andrew and Le Brun, Nicolas (2016) Biochemical properties of Paracoccus denitrificans FnrP:Reactions with molecular oxygen and nitric oxide. JBIC Journal of Biological Inorganic Chemistry, 21 (1). pp. 71-82. ISSN 0949-8257

Bradley, Justin M., Le Brun, Nick E. and Moore, Geoffrey R. (2016) Commentary: Ferritins: Furnishing proteins with iron. Journal of Rare Diseases Research and Treatment, 1 (3). pp. 22-24.

Bradley, Justin M., Svistunenko, Dimitri A., Lawson, Tamara L., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E. (2015) Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin. Angewandte Chemie International Edition, 127 (49). 14976–14980. ISSN 1433-7851

Pfaffen, Stephanie, Bradley, Justin, Abdulqadir, Raz, Firme, Marlo R., Moore, Geoff, Le Brun, Nick and Murphy, Michael (2015) A diatom ferritin optimized for iron oxidation but not iron storage. The Journal of Biological Chemistry, 290. pp. 28416-28427. ISSN 1083-351X

Ibrahim, Susan A, Crack, Jason C, Rolfe, Matthew D, Borrero-de Acuňa, Jose Manuel, Thomson, Andrew J, Le Brun, Nick E, Schobert, Max, Stapleton, Melanie R and Green, Jeffrey (2015) Three Pseudomonas putida FNR Family Proteins with Different Sensitivities to O2. The Journal of Biological Chemistry, 290. pp. 16812-16823. ISSN 1083-351X

Handley, Rebecca A, Mulholland, Francis, Reuter, Mark, Ramachandran, Vinoy K, Musk, Heather, Clissold, Leah, Le Brun, Nick E and van Vliet, Arnoud H M (2015) PerR controls oxidative stress defence and aerotolerance but not motility-associated phenotypes of Campylobacter jejuni. Microbiology, 161. pp. 1524-1536. ISSN 1350-0872

Crack, Jason, Munnoch, John Tyson, Dodd, Erin, Knowles, Felicity, Al-Bassam, Mahmoud, Kamali, Saeed, Holland, Ashley, Cramer, Stephen, Hamilton, Christopher, Johnson, Michael, Thomson, Andrew, Hutchings, Matthew and Le Brun, Nick (2015) NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function. The Journal of Biological Chemistry, 290. pp. 12689-12704. ISSN 1083-351X

Wong, Steve, Grigg, Jason, Le Brun, Nick, Moore, Geoff, Murphy, Michael and Mauk, Grant (2015) The B-type Channel is a Major Route for Iron Entry into the Ferroxidase Center and Central Cavity of Bacterioferritin. The Journal of Biological Chemistry, 290 (6). pp. 3732-3739. ISSN 1083-351X

Crack, Jason C., Stapleton, Melanie R., Green, Jeffrey, Thomson, Andrew J. and Le Brun, Nick E. (2014) Influence of association state and DNA binding on the O2-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator. Biochemical Journal, 463 (1). pp. 83-92. ISSN 0264-6021

Crack, Jason C, Green, Jeffrey, Thomson, Andrew J and Le Brun, Nick E (2014) Iron-sulfur clusters as biological sensors:the chemistry of reactions with molecular oxygen and nitric oxide. Accounts of Chemical Research, 47 (10). pp. 3196-205. ISSN 1520-4898

Bradley, Justin M, Moore, Geoffrey R and Le Brun, Nick E (2014) Mechanisms of iron mineralization in ferritins:one size does not fit all. JBIC Journal of Biological Inorganic Chemistry, 19 (6). pp. 775-785. ISSN 0949-8257

Crack, Jason C, Green, Jeffrey, Thomson, Andrew J and Le Brun, Nick E (2014) Techniques for the production, isolation, and analysis of iron-sulfur proteins. Methods in Molecular Biology, 1122. pp. 33-48. ISSN 1064-3745

Le Brun, Nick (2014) Binding, Transport and Storage of Copper in Prokaryotes. In: Binding, Transport and Storage of Metal Ions in Biological Cells. RSC Metallobiology. RSC Publishing, Camridge, pp. 461-523. ISBN 978-1-84973-599-5

Pfaffen, Stephanie, Abdulqadir, Raz, Le Brun, Nick E and Murphy, Michael E P (2013) Mechanism of ferrous iron binding and oxidation by ferritin from a pennate diatom. The Journal of Biological Chemistry, 288 (21). pp. 14917-14925. ISSN 1083-351X

Crack, Jason C, Stapleton, Melanie R, Green, Jeffrey, Thomson, Andrew J and Le Brun, Nick E (2013) Mechanism of [4Fe-4S](Cys)4 cluster nitrosylation is conserved among NO-responsive regulators. The Journal of Biological Chemistry, 288 (16). pp. 11492-502. ISSN 1083-351X

Raven, Emma, McMaster, Jonathan, Reedijk, Jan, Robinson, Nigel J and Le Brun, Nick (2013) Bioinorganic chemistry. Dalton Transactions, 42 (9). pp. 3027-8. ISSN 1477-9226

Zhang, Bo, Crack, Jason C., Subramanian, Sowmya, Green, Jeffrey, Thomson, Andrew J., Le Brun, Nick E. and Johnson, Michael K. (2012) Reversible cycling between cysteine persulfide-ligated [2Fe-2S] and cysteine-ligated [4Fe-4S] clusters in the FNR regulatory protein. Proceedings of the National Academy of Sciences, 109 (39). pp. 15734-15739. ISSN 0027-8424

Zhou, Liang, Singleton, Chloe, Hecht, Oliver, Moore, Geoffrey R. and Le Brun, Nick E. (2012) Cu(I)- and proton-binding properties of the first N-terminal soluble domain of Bacillus subtilis CopA. FEBS Journal, 279 (2). pp. 285-298. ISSN 1742-4658

Crack, JC, Green, J, Hutchings, M, Thomson, AJ and Le Brun, NE (2012) Bacterial iron-sulfur regulatory proteins as biological sensor-switches. Antioxidants & Redox Signaling, 17. pp. 1215-1231. ISSN 1523-0864

Crack, JC, Green, J, Thomson, AJ and Le Brun, NE (2012) Iron–sulfur sensor-regulators. Current Opinion in Chemical Biology, 16. pp. 35-44. ISSN 1879-0402

Wong, Steve G., Abdulqadir, Raz, Le Brun, Nick E., Moore, Geoffrey R. and Mauk, A. Grant (2012) Fe-haem bound to Escherichia colibacterioferritin accelerates iron core formation by an electron transfer mechanism. Biochemical Journal, 444 (3). pp. 553-560. ISSN 0264-6021

Zhou, Liang, Singleton, Chloe and Le Brun, Nick E. (2012) CopAb, the second N-terminal soluble domain of Bacillus subtilis CopA, dominates the Cu(i)-binding properties of CopAab. Dalton Transactions, 41 (19). pp. 5939-5948. ISSN 1477-9226

White, GF, Singleton, C, Todd, JD, Cheesman, MR, Johnston, AWB and Le Brun, NE (2011) Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization. FEBS Journal, 278 (12). pp. 2011-2021. ISSN 1742-4658

Yasmin, S, Andrews, S. C., Moore, Geoff and Le Brun, Nick (2011) A New Role for Heme, Facilitating Release of Iron from the Bacterioferritin Iron Biomineral. The Journal of Biological Chemistry, 286 (5). pp. 3473-3483. ISSN 1083-351X

Crack, Jason C., Smith, Laura J., Stapleton, Melanie R., Peck, Jamie, Watmough, Nicholas J., Buttner, Mark J., Buxton, Roger S., Green, Jeffrey, Oganesyan, Vasily S., Thomson, Andrew J. and Le Brun, Nick E. (2011) Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins. Journal of the American Chemical Society, 133 (4). pp. 1112-1121. ISSN 0002-7863

Yasmin, S, Andrews, SC, Moore, GR and Le Brun, NE (2011) A new role for heme: facilitating release of iron from the bacterioferritin iron biomineral. The Journal of Biological Chemistry, 286. pp. 3473-3483. ISSN 1083-351X

Smith, Laura J., Stapleton, Melanie R., Fullstone, Gavin J. M., Crack, Jason C., Thomson, Andrew J., Le Brun, Nick E., Hunt, Debbie M., Harvey, Evelyn, Adinolfi, Salvatore, Buxton, Roger S. and Green, Jeffrey (2010) Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide sensitive iron-sulphur cluster. Biochemical Journal, 432 (3). pp. 417-427. ISSN 0264-6021

Le Brun, NE, Crow, A, Murphy, MEP, Mauk, AG and Moore, GR (2010) Iron core mineralisation in prokaryotic ferritins. Biochimica et Biophysica Acta, 1800 (8). pp. 732-44. ISSN 0006-3002

Singleton, C, White, G, Todd, JD, Marritt, S, Cheesman, M, Johnston, A and Le Brun, N (2010) Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum. The Journal of Biological Chemistry, 285 (21). pp. 16023-16031. ISSN 1083-351X

Tucker, NP, Le Brun, NE, Dixon, R and Hutchings, MI (2010) There's NO stopping NsrR, a global regulator of the bacterial NO stress response. Trends in Microbiology, 18 (4). pp. 149-156. ISSN 1878-4380

Kirkwood, M, Le Brun, N, Todd, JD and Johnston, AWB (2010) The dddP gene of Roseovarius nubinhibens encodes a novel lyase that cleaves dimethylsulfoniopropionate into acrylate plus dimethyl sulfide. Microbiology, 156 (6). pp. 1900-1906. ISSN 1350-0872

Kirkwood, M, Le Brun, NE, Todd, JD and Johnston, AWB (2010) The ddP gene of Roseovarius nubinhibens encodes a novel lyase that cleaves dimethylsulfoniopropionate into acrylate plus dimethyl sulfide. Microbiology, 156. pp. 1900-1906. ISSN 1465-2080

Crack, Jason, den Hengst, Chris D., Jakimowicz, Piotr, Subramanian, Sowmya, Johnson, Michael K., Buttner, Mark J., Thomson, Andrew J. and Le Brun, Nick (2009) Characterization of [4Fe-4S]-Containing and Cluster-Free Forms ofStreptomycesWhiD. Biochemistry, 48 (51). pp. 12252-12264.

Hearnshaw, Stephen, West, Claire, Singleton, Chloe, Zhou, Liang, Kihlken, Margaret A., Strange, Richard W., Le Brun, Nick E. and Hemmings, Andrew M. (2009) A Tetranuclear Cu(I) Cluster in the Metallochaperone Protein CopZ. Biochemistry, 48 (40). pp. 9324-9326. ISSN 0006-2960

Crow, Allister, Lewin, Allison, Hecht, Oliver, Carlsson Moller, Mirja, Moore, Geoff, Hederstedt, L. and Le Brun, Nick (2009) Crystal Structure and Biophysical Properties of Bacillus subtilis BdbD: AN OXIDIZING THIOL:DISULFIDE OXIDOREDUCTASE CONTAINING A NOVEL METAL SITE. The Journal of Biological Chemistry, 284 (35). pp. 23719-23733. ISSN 1083-351X

Lawson, Tamara L., Crow, Allister, Lewin, Allison, Yasmin, Samina, Moore, Geoff and Le Brun, Nick (2009) Monitoring the Iron Status of the Ferroxidase Center ofEscherichia coliBacterioferritin Using Fluorescence Spectroscopy. Biochemistry, 48 (38). pp. 9031-9039.

Wong, Steve G., Tom-Yew, Stacey A. L., Lewin, Allison, Le Brun, Nick, Moore, Geoffrey R., Murphy, Michael E. P. and Mauk, A. Grant (2009) Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation. The Journal of Biological Chemistry, 284 (28). pp. 18873-18881. ISSN 1083-351X

Crow, Allister, Lawson, Tamara L., Lewin, Allison, Moore, Geoff and Le Brun, Nick (2009) Structural Basis for Iron Mineralization by Bacterioferritin. Journal of the American Chemical Society, 131 (19). pp. 6808-6813.

Crow, Allister, Liu, Yiming, Carlsson Moller, Mirja, Le Brun, Nick and Hederstedt, Lars (2009) Structure and Functional Properties of Bacillus subtilis Endospore Biogenesis Factor StoA. The Journal of Biological Chemistry, 284 (15). pp. 10056-10066. ISSN 1083-351X

Jervis, Adrian J., Crack, Jason C., White, Gaye, Artymiuk, Peter J., Cheesman, Myles R., Thomson, Andrew J., Le Brun, Nick E. and Green, Jeffrey (2009) The O2 sensitivity of the transcription factor FNR is controlled by Ser24 modulating the kinetics of [4Fe-4S] to [2Fe-2S] conversion. Proceedings of the National Academy of Sciences of the United States of America, 106 (12). pp. 4659-4664.

Green, Jeffrey, Crack, Jason, Thomson, Andrew J. and Le Brun, Nick (2009) Bacterial sensors of oxygen. Current Opinion in Microbiology, 12 (2). pp. 145-151. ISSN 1879-0364

Singleton, Chloe, Hearnshaw, Stephen, Zhou, Liang, Le Brun, Nick and Hemmings, Andrew (2009) Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA. Biochemical Journal, 424 (3). pp. 347-356. ISSN 0264-6021

Singleton, Chloe and Le Brun, Nick (2009) The N-terminal soluble domains of Bacillus subtilis CopA exhibit a high affinity and capacity for Cu(i) ions. Dalton Transactions (4). p. 688. ISSN 1477-9234

Tucker, Nicholas P., Hicks, Matthew G., Clarke, Thomas A., Crack, Jason C., Chandra, Govind, Le Brun, Nick E., Dixon, Ray and Hutchings, Matthew I. (2008) The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster. PLoS One, 3 (11). ISSN 1932-6203

Hodson, Christopher T. C., Lewin, Allison, Hederstedt, L. and Le Brun, Nick E. (2008) The Active-Site Cysteinyls and Hydrophobic Cavity Residues of ResA Are Important for Cytochrome c Maturation in Bacillus subtilis. Journal of Bacteriology, 190 (13). pp. 4697-4705.

Kihlken, M.A., Singleton, C and Le Brun, N. E. (2008) Distinct characteristics of Ag+ and Cd2+ binding to CopZ from Bacillus subtilis. JBIC Journal of Biological Inorganic Chemistry, 13 (6). pp. 1011-1023. ISSN 0949-8257

Crack, Jason, Gaskell, Alisa A., Green, Jeffrey, Cheesman, Myles, Le Brun, Nick and Thomson, Andrew J. (2008) Influence of the Environment on the [4Fe−4S]2+ to [2Fe−2S]2+ Cluster Switch in the Transcriptional Regulator FNR. Journal of the American Chemical Society, 130 (5). pp. 1749-1758.

Crack, Jason C., Jervis, Adrian J., Gaskell, Alice, White, Gaye F., Green, Jeffrey, Thomson, Andrew J. and Le Brun, Nick E. (2008) Signal perception by FNR: the role of the iron–sulfur cluster. Biochemical Society Transactions, 36 (6). p. 1144. ISSN 0300-5127

Crack, Jason C., Le Brun, Nick E., Thomson, Andrew J., Green, Jeffrey and Jervis, Adrian J. (2008) Reactions of Nitric Oxide and Oxygen with the Regulator of Fumarate and Nitrate Reduction, a Global Transcriptional Regulator, during Anaerobic Growth of Escherichia coli. Methods in Enzymology, 437. pp. 191-209. ISSN 1557-7988

Lewin, Allison, Crow, Allister, Hodson, Christopher T. C., Hederstedt, Lars and Le Brun, Nick E. (2008) Effects of substitutions in the CXXC active-site motif of the extracytoplasmic thioredoxin ResA. Biochemical Journal, 414 (1). p. 81. ISSN 0264-6021

Singleton, Chloe, Banci, Lucia, Ciofi-Baffoni, Simone, Tenori, Leonardo, Kihlken, Margaret A., Boetzel, Ruth and Le Brun, Nick E. (2008) Structure and Cu(I)-binding properties of the N-terminal soluble domains of Bacillus subtilis CopA. Biochemical Journal, 411 (3). p. 571. ISSN 0264-6021

Zhou, Liang, Singleton, Chloe and Le Brun, Nick E. (2008) High Cu(I) and low proton affinities of the CXXC motif of Bacillus subtilis CopZ. Biochemical Journal, 413 (3). p. 459. ISSN 0264-6021

Gaskell, Alisa A., Crack, Jason C., Kelemen, Gabriella K., Hutchings, Matthew I. and Le Brun, Nick E. (2007) RsmA, an anti-sigma factor from Streptomyces coelicolor, modulates its activity through a [2Fe-2s] cluster cofactor. Journal of Biological Chemistry, 282 (43). pp. 31812-31820. ISSN 0021-9258

Crack, J. C., Green, J., Cheesman, M. R., Le Brun, N. E. and Thomson, A. J. (2007) Superoxide-mediated amplification of the oxygen-induced switch from 4Fe-4S to 2Fe-2S clusters in the transcriptional regulator FNR. Proceedings of the National Academy of Sciences, 104 (7). pp. 2092-2097. ISSN 0027-8424

Lewin, Allison, Crow, Allister, Oubrie, Arthur and Le Brun, Nick E. (2006) Molecular Basis for Specificity of the Extracytoplasmic Thioredoxin ResA. Journal of Biological Chemistry, 281. pp. 35467-35477. ISSN 1083-351X

Crow, A., Le Brun, N. E. and Oubrie, A. (2005) The role of ResA in type II cytochrome c maturation. Biochemical Society Transactions, 33 (1). pp. 149-151. ISSN 1470-8752

Crow, Allister, Acheson, Richard M., Le Brun, Nick E. and Oubrie, Arthur (2004) Structural Basis of Redox-coupled Protein Substrate Selection by the Cytochrome c Biosynthesis Protein ResA. Journal of Biological Chemistry, 279. pp. 23654-23660. ISSN 1083-351X

Malone, Simon A., Lewin, Allison, Kilic, Mehmet A., Svistunenko, Dimitri A., Cooper, Chris E., Wilson, Michael T., Le Brun, Nick E., Spiro, Stephen and Moore, Geoffrey R. (2004) Protein-Template-Driven Formation of Polynuclear Iron Species. Journal of the American Chemical Society, 126 (2). pp. 496-504.

Kihiken, Margaret A., Leech, Andrew P. and LeBrun, Nick E. (2002) Copper-mediated dimerization of CopZ, a predicted copper chaperone from Bacilus subtilis. Biochemical Journal, 368 (3). pp. 729-739.

Le Brun, Nick E., Cheesman, Myles R., Thomson, Andrew J., Moore, Geoffrey R., Andrews, Simon C., Guest, John R. and Harrison, Pauline M. (1993) An EPR investigation of non-haem iron sites in Escherichia coli bacterioferritin and their interaction with phosphate. FEBS Letters, 323 (3). pp. 261-266. ISSN 0014-5793

Cheesman, Myles, Le Brun, Nick, Kadir, Fahmi H A, Thomson, Andrew J, Moore, Geoff R, Andrews, S. C., Harrison, P M, Smith, J M A and Yewdall, S J (1993) Haem and non-haem iron sites in E.coli bacterioferritin: spectroscopic and model building studies. Biochemical Journal, 292 (1). pp. 47-56. ISSN 0264-6021

This list was generated on Wed Jul 6 15:24:36 2022 UTC.