Iron–sulfur clusters as inhibitors and catalysts of viral replication

Honarmand Ebrahimi, Kourosh, Ciofi-Baffoni, Simone, Hagedoorn, Peter-Leon, Nicolet, Yvain, Le Brun, Nick E. ORCID: https://orcid.org/0000-0001-9780-4061, Hagen, Wilfred R. and Armstrong, Fraser A. (2022) Iron–sulfur clusters as inhibitors and catalysts of viral replication. Nature Chemistry, 14 (3). 253–266. ISSN 1755-4330

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Abstract

A virus hijacks host cellular machineries and metabolites in order to reproduce. In response, the innate immune system activates different processes to fight back. Although many aspects of these processes have been well investigated, the key roles played by iron–sulfur [FeS] clusters, which are among the oldest classes of bio-inorganic cofactors, have barely been considered. Here we discuss how several [FeS] cluster-containing proteins activate, support and modulate the innate immune response to restrict viral infections, and how some of these proteins simultaneously support the replication of viruses. We also propose models of function of some proteins in the innate immune response and argue that [FeS] clusters in many of these proteins act as biological ‘fuses’ to control the response. We hope this overview helps to inspire future research in the emerging field of bio-inorganic virology/immunology and that such studies may reveal new molecular insight into the links between viral infections and diseases like cancer and neurodegeneration.

Item Type: Article
Additional Information: Acknowledgements: We dedicate this Review to the memory of Andrew Thomson, a true pioneer of iron–sulfur cluster biochemistry who inspired us all in different ways. Funding Information: We acknowledge support from the European COST action FeSBioNET. K.H.E. is grateful for support from the European Molecular Biology Organization (EMBO; ALTF 157-2015), the Edward Penley Abraham Research Fund (RF259) and Cancer Research UK (CRUK) Oxford (CRUKDF-0221-KHE). Y.N. thanks the Commissariat à l'Energie Atomique (CEA) for institutional support. N.E.L.B. thanks the Biotechnology and Biological Sciences Research Council (BBSRC; grant no. BB/S001018/1). S.C.-B. acknowledges support from the Fondazione Cassa di Risparmio di Firenze (grant no. CRF2018.0920).
Uncontrolled Keywords: chemistry(all),chemical engineering(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 01 Apr 2022 15:30
Last Modified: 22 Oct 2022 17:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/84422
DOI: 10.1038/s41557-021-00882-0

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