Iron–sulfur sensor-regulators

Crack, Jason C., Green, Jeffrey, Thomson, Andrew J. and Le Brun, Nick E. (2012) Iron–sulfur sensor-regulators. Current Opinion in Chemical Biology, 16. pp. 35-44. ISSN 1879-0402

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Abstract

Regulatory proteins that contain an iron–sulfur cluster cofactor constitute a group that is growing both in number and importance, with a range of functions that include sensing of molecular oxygen, stress response, and iron regulation. In all cases, the cluster plays a central role, as a sensory module, in controlling the activity of the regulator. In some cases, the cluster is required for the protein to attain its regulatory form, while in others the active form requires loss or modification of the cluster. In this way, nature has exploited the inherent reactivity of iron–sulfur clusters. Here, we focus on recent advances that provide new insight into the remarkable chemistries exhibited by these regulators, and how they achieve the required levels of sensitivity and specificity.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences
Depositing User:	Users 2731 not found.
Date Deposited:	21 Mar 2012 21:51
Last Modified:	28 Mar 2025 02:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/38434
DOI:	10.1016/j.cbpa.2012.02.009

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