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ToolsHearnshaw, Stephen, West, Claire, Singleton, Chloe, Zhou, Liang, Kihlken, Margaret A., Strange, Richard W., Le Brun, Nick E. and Hemmings, Andrew M. (2009) A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ. Biochemistry, 48 (40). pp. 9324-9326. ISSN 0006-2960
Full text not available from this repository. (Request a copy)Abstract
Copper trafficking proteins and copper-sensitive regulators are often found to be able to bind multiple Cu(I) ions in the form of Cu(I) clusters. We have determined the high-resolution X-ray crystal structure of an Atx1-like copper chaperone protein from Bacillus subtilis containing a novel tetranuclear Cu(I) cluster. The identities and oxidation states of the cluster ions were established unambiguously by refinement of X-ray energy-dependent anomalous scattering factors. The [Cu4(S-Cys)4(N-His)2] cluster geometry provides new structural insights into not only the binding of multiple cuprous ions by metallochaperones but also protein-associated tetranuclear Cu(I) clusters, including those found in eukaryotic copper-responsive transcription factors.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Groups > Plant Sciences Faculty of Medicine and Health Sciences > Research Centres > Population Health |
| Depositing User: | Users 2731 not found. |
| Date Deposited: | 12 Sep 2011 09:51 |
| Last Modified: | 28 Mar 2025 03:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/25387 |
| DOI: | 10.1021/bi9011995 |
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