Hearnshaw, Stephen, West, Claire, Singleton, Chloe, Zhou, Liang, Kihlken, Margaret A., Strange, Richard W., Le Brun, Nick E. and Hemmings, Andrew M. (2009) A Tetranuclear Cu(I) Cluster in the Metallochaperone Protein CopZ. Biochemistry, 48 (40). pp. 9324-9326. ISSN 0006-2960

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Abstract

Copper trafficking proteins and copper-sensitive regulators are often found to be able to bind multiple Cu(I) ions in the form of Cu(I) clusters. We have determined the high-resolution X-ray crystal structure of an Atx1-like copper chaperone protein from Bacillus subtilis containing a novel tetranuclear Cu(I) cluster. The identities and oxidation states of the cluster ions were established unambiguously by refinement of X-ray energy-dependent anomalous scattering factors. The [Cu4(S-Cys)4(N-His)2] cluster geometry provides new structural insights into not only the binding of multiple cuprous ions by metallochaperones but also protein-associated tetranuclear Cu(I) clusters, including those found in eukaryotic copper-responsive transcription factors.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry
Depositing User:	Users 2731 not found.
Date Deposited:	12 Sep 2011 09:51
Last Modified:	17 Sep 2020 23:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/25387
DOI:	10.1021/bi9011995

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