Electron transfer from haem to the di-iron ferroxidase centre in bacterioferritin

Pullin, Jacob, Bradley, Justin M., Moore, Geoffrey R., Le Brun, Nick E. ORCID: https://orcid.org/0000-0001-9780-4061, Wilson, Michael T. and Svistunenko, Dimitri A. (2021) Electron transfer from haem to the di-iron ferroxidase centre in bacterioferritin. Angewandte Chemie-International Edition, 60 (15). pp. 8376-8379. ISSN 1433-7851

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The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other ferritins in that they contain haem groups. It is acknowledged that the two iron motifs in bacterioferritins, the di-nuclear ferroxidase centre and the haem B group, play key roles in two opposing processes, iron sequestration and iron mobilisation, respectively, and the two redox processes are independent. Herein, we show that in Escherichia coli bacterioferritin, there is an electron transfer pathway from the haem to the ferroxidase centre suggesting a new role(s) haem might play in bacterioferritins.

Item Type: Article
Uncontrolled Keywords: electron transfer,ferritins,ferroxidase centre,metalloproteins,stopped-flow spectrophotometry,catalysis,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1500/1503
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 29 Jan 2021 01:01
Last Modified: 29 Mar 2024 11:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/78313
DOI: 10.1002/anie.202015965


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