Diversity of Fe2+ entry and oxidation in ferritins

Bradley, Justin M., Moore, Geoffrey R. and Le Brun, Nick E. ORCID: https://orcid.org/0000-0001-9780-4061 (2017) Diversity of Fe2+ entry and oxidation in ferritins. Current Opinion in Chemical Biology, 37. 122–128. ISSN 1367-5931

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The essential metal iron presents two major problems for life: it is potentially highly toxic due to its redox activity, and its extremely low solubility in aqueous solution in the presence of O2 can make it hard to acquire and store safely. Ferritins are part of nature’s answer to these problems, as they store iron in a safe but accessible form in all types of cells. How they achieve this has been the subject of intense research for several decades. Here, we highlight recent progress in elucidating the routes by which Fe2+ ions access the catalytic ferroxidase centers, and the mechanisms by which Fe2+ is oxidized. Emerging from this is a picture of diversity, both in terms of Fe2+ entry pathways and the roles played by the structurally distinct diiron ferroxidase centers.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017)
Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
Faculty of Science > Research Groups > Chemistry of Life Processes
Depositing User: Pure Connector
Date Deposited: 06 Mar 2017 09:37
Last Modified: 21 Oct 2022 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/62862
DOI: 10.1016/j.cbpa.2017.02.027

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