Fe Transport and Storage Related to Humans and Pathogens and Oxygen

Theil, E. C. and Le Brun, N. E. ORCID: https://orcid.org/0000-0001-9780-4061 (2013) Fe Transport and Storage Related to Humans and Pathogens and Oxygen. In: Bioinorganic Fundamentals and Applications. Elsevier, pp. 21-33. ISBN 9780080965291

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Abstract

Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe3+O mineralization as iron concentrates and antioxidants. Direct Fe2+/riboregulator interactions control ferritin protein synthesis in animals, through an Fe2+ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe2+ from pathogens to intracellular ferritins and pathogen use of H2O2 consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.

Item Type:	Book Section
Uncontrolled Keywords:	antoxidant,biominerals,ferritin,iron,iron channels,noncoding riboregulator (ire) - rna,oxidoreductase,protein nanocages,general chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1600
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Life Processes (former - to 2025) Faculty of Science > Research Groups > Pharmacology and Biological Chemistry
Related URLs:	https://www.scopus.com/pages/publication...
Depositing User:	LivePure Connector
Date Deposited:	18 Jun 2025 08:30
Last Modified:	18 Jun 2026 22:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99595
DOI:	10.1016/B978-0-08-097774-4.00302-8

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