Fe Transport and Storage Related to Humans and Pathogens and Oxygen

Theil, E. C. and Le Brun, N. E. (2013) Fe Transport and Storage Related to Humans and Pathogens and Oxygen. In: Bioinorganic Fundamentals and Applications. Elsevier, pp. 21-33. ISBN 9780080965291

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Abstract

Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe3+O mineralization as iron concentrates and antioxidants. Direct Fe2+/riboregulator interactions control ferritin protein synthesis in animals, through an Fe2+ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe2+ from pathogens to intracellular ferritins and pathogen use of H2O2 consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.

Item Type:	Book Section
Uncontrolled Keywords:	antoxidant,biominerals,ferritin,iron,iron channels,noncoding riboregulator (ire) - rna,oxidoreductase,protein nanocages,chemistry(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Life Processes
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	18 Jun 2025 08:30
Last Modified:	18 Jun 2025 08:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/99595
DOI:	10.1016/B978-0-08-097774-4.00302-8

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