Items where Author is "Searcey, Mark"

Article

Goddard, Zoë R., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Osbourn, Anne (2024) Advances in triterpene drug discovery. Trends in Pharmacological Sciences, 45 (11). pp. 964-968. ISSN 0165-6147

Hamshaw, Isabel ORCID: https://orcid.org/0000-0001-6445-0738, Cominetti, Marco, Nana-Akyin, Princess, Ho Yee Ho, Ernie, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 (2024) IS4-FAM, a fluorescent tool to study CXCR4 affinity and competitive antagonism in native cancer cells. Pharmacology Research and Perspectives, 12 (5). ISSN 2052-1707

Hayward, Deanne, Goddard, Zoë R. ORCID: https://orcid.org/0000-0002-7900-1553, Cominetti, Marco M. D., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406 (2024) Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction. Chemical Communications, 60 (63). pp. 8228-8231. ISSN 1359-7345

Cominetti, Marco M. D., Goddard, Zoë R. ORCID: https://orcid.org/0000-0002-7900-1553, Hood, Bethany R., Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2024) Borylation via iridium catalysed C–H activation: a new concise route to duocarmycin derivatives. Organic & Biomolecular Chemistry, 22 (27). pp. 5603-5607. ISSN 1477-0520

Steverding, Dietmar, Tinson, Ryan A. J., Piras, Monica, Wren, Stephen P., Rushworth, Stuart A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2024) Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug. Experimental Parasitology, 260. ISSN 0014-4894

Hamshaw, Isabel ORCID: https://orcid.org/0000-0001-6445-0738, Cominetti, Marco M. D., Lai, Wing-Yee, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 (2023) The development of potent, competitive CXCR4 antagonists for the prevention of cancer metastasis. Biochemical Pharmacology, 218. ISSN 0006-2952

Green, Jonathan, Tinson, Ryan A. J., Betts, Jacob H. J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2023) Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue. Bioorganic & Medicinal Chemistry, 92. ISSN 0968-0896

Ivens, Eleanor, Cominetti, Marco M. D. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2022) Junctions in DNA: underexplored targets for therapeutic intervention. Bioorganic & Medicinal Chemistry, 69. ISSN 0968-0896

Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Nadzirin, Izzuddin Bin, Cominetti, Marco, Hickey, Harry, Cullum, Sean A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Schmid, Ralf and Fountain, Samuel J. ORCID: https://orcid.org/0000-0002-6028-0548 (2022) Structural basis of the negative allosteric modulation of 5-BDBD at human P2X4 receptors. Molecular Pharmacology, 101 (1). pp. 33-44. ISSN 1521-0111

Nadzirin, Izzuddin Bin, Fortuny‐Gomez, Anna, Ngum, Neville, Richards, David, Ali, Seema, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Fountain, Samuel J. ORCID: https://orcid.org/0000-0002-6028-0548 (2021) Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition. British Journal of Pharmacology, 178 (24). pp. 4859-4872. ISSN 0007-1188

Ortuzar, Natalia, Karu, Kersti, Presa, Daniela, Morais, Goreti R., Sheldrake, Helen M., Shnyder, Steve D., Barnieh, Francis M., Loadman, Paul M., Patterson, Laurence H., Pors, Klaus and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2021) Probing cytochrome P450 (CYP) bioactivation with chloromethylindoline bioprecursors derived from the duocarmycin family of compounds. Bioorganic & Medicinal Chemistry, 40. ISSN 0968-0896

M. M. D. Cominetti, Marco, Goddard, Zoë R. ORCID: https://orcid.org/0000-0002-7900-1553, Howman, Chloe E., O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2021) Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesis. Tetrahedron Letters, 72. ISSN 0040-4039

Goddard, Zoë Rachael ORCID: https://orcid.org/0000-0002-7900-1553, Beekman, Andrew Michael ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951, Chambrier, Isabelle, Cook, Michael J., Marin, Maria J. ORCID: https://orcid.org/0000-0001-8021-5498, Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2021) Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers. RSC Medicinal Chemistry, 12 (2). pp. 288-292. ISSN 2632-8682

Goddard, Zoë Rachael ORCID: https://orcid.org/0000-0002-7900-1553, Marin, Maria J. ORCID: https://orcid.org/0000-0001-8021-5498, Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2020) Active targeting of gold nanoparticles as cancer therapeutics. Chemical Society Reviews, 49 (23). pp. 8774-8789. ISSN 0306-0012

Cartwright, Oliver Charles, Beekman, Andrew Michael ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2020) A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity. Bioconjugate Chemistry, 31 (7). 1745–1749. ISSN 1043-1802

Atli, Nursabah, Harvey, James, Kay, Colin, Draijer, Richard, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 (2020) Synthetic analogues of ferulic acidexert anti-inflammatory and antioxidanteffects in human monocytic cells. British Journal of Pharmacology, 177 (11). p. 2572. ISSN 0007-1188

Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco, Cartwright, Oliver, Boger, Dale L. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2019) A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase. MedChemComm, 10 (12). pp. 2170-2174. ISSN 2040-2503

Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951, Angulo Alvarez, Jesus ORCID: https://orcid.org/0000-0001-7250-5639 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2019) Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design. Chemical Science, 10 (16). pp. 4502-4508. ISSN 2041-6520

Williams, Morwen, Bertrand, Benoît, Hughes, David L., Waller, Zoe Ann Ella, Schmidt, Claudia, Ott, Ingo, O'Connell, Maria Anne ORCID: https://orcid.org/0000-0002-0267-0951, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Bochmann, Manfred ORCID: https://orcid.org/0000-0001-7736-5428 (2018) Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies. Metallomics, 10 (11). pp. 1655-1666. ISSN 1756-5901

Williams, Morwen RM, Bertrand, Benoît, Fernandez-Cestau, Julio, Waller, Zoë AE, O'Connell, Maria A ORCID: https://orcid.org/0000-0002-0267-0951, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Bochmann, Manfred ORCID: https://orcid.org/0000-0001-7736-5428 (2018) Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations. Dalton Transactions, 47 (38). pp. 13523-13534. ISSN 1477-9226

Steel, Richard J., O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2018) Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction. Bioorganic & Medicinal Chemistry Letters, 28 (16). pp. 2728-2731. ISSN 0960-894X

Williams, Morwen, Green, Adam I, Fernandez-Cestau, Julio, Hughes, David L, O'Connell, Maria Anne ORCID: https://orcid.org/0000-0002-0267-0951, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Bertrand, Benoit and Bochmann, Manfred ORCID: https://orcid.org/0000-0001-7736-5428 (2017) (C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties. Dalton Transactions, 46 (39). 13397–13408. ISSN 1477-9226

Bertrand, Benoît, Fernandez-Cestau, Julio, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Cominetti, Marco M. D., Waller, Zoe A. E., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Bochmann, Manfred ORCID: https://orcid.org/0000-0001-7736-5428 (2017) Cytotoxicity of pyrazine-based cyclometalated (C^Npz^C)Au(III) carbene complexes: Impact of the nature of the ancillary ligand on the biological properties. Inorganic Chemistry, 56 (10). 5728–5740. ISSN 0020-1669

Austin, Michael J., Hearnshaw, Stephen J., Mitchenall, Lesley A., McDermott, Paul J., Howell, Lesley A., Maxwell, Anthony and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2016) A natural product inspired fragment-based approach towards the development of novel anti-bacterial agents. MedChemComm, 7 (7). pp. 1387-1391. ISSN 2040-2503

Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Goffin, Sarah, Gandhi, Daivik, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Howell, Lesley (2016) Unveiling the "three finger pharmacophore" required for p53-MDM2 inhibition by saturation transfer difference NMR initial growth rates approach. Chemistry - A European Journal, 22 (17). pp. 5858-5862. ISSN 0947-6539

Cominetti, Marco, Goffin, Sarah, Raffel, Ewan, Turner, Kerrie, Ramoutar, Jordann, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Howell, Lesley and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2015) Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin. Bioorganic & Medicinal Chemistry Letters, 25 (21). pp. 4878-4880. ISSN 0960-894X

Stephenson, Michael ORCID: https://orcid.org/0000-0002-2594-1806, Howell, Lesley, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Fox, Keith R., Adcock, Claire, Kingston, Jenny, Sheldrake, Helen, Pors, Klaus, Collingwood, Stephen P. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2015) Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity. The Journal of Organic Chemistry, 80 (19). 9454–9467. ISSN 0022-3263

Vinader, Victoria, Sadiq, Maria, Sutherland, Mark, Huang, Menying, Loadman, Paul, Elsalem, Lina, Shnyder, Steven, Cui, Hongjuan, Afarinkia, Kamyar, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Patterson, Laurence and Pors, Klaus (2015) Probing cytochrome P450-mediated activation with a truncated azinomycin analogue. MedChemComm, 6. pp. 187-191. ISSN 2040-2511

Waller, Zoë A E, Howell, Lesley A, Macdonald, Colin J, O'Connell, Maria A ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2014) Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Biochemical and Biophysical Research Communications, 447 (1). pp. 128-32. ISSN 0006-291X

Sheldrake, Helen M., Travica, Sandra, Johansson, Inger, Loadman, Paul M., Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J., Reuillon, Tristan, Shnyder, Steven D., Mkrtchian, Souren, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Ingelman-Sundberg, Magnus, Patterson, Laurence H. and Pors, Klaus (2013) Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity. Journal of Medicinal Chemistry, 56 (15). pp. 6273-6277. ISSN 0022-2623

Marin, MJ ORCID: https://orcid.org/0000-0001-8021-5498, Rackham, Benjamin D., Round, Andrew N. ORCID: https://orcid.org/0000-0001-9026-0620, Howell, Lesley A., Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2013) A rapid screen for molecules that form duplex to duplex crosslinks in DNA. Chemical Communications, 49 (80). p. 9113. ISSN 1359-7345

Rackham, Benjamin D., Howell, Lesley A., Round, Andrew N. ORCID: https://orcid.org/0000-0001-9026-0620 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2013) Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy. Organic & Biomolecular Chemistry, 11 (48). pp. 8340-8347. ISSN 1477-0520

Sutherland, Mark, Gill, Jason H, Loadman, Paul M, Laye, Jonathan P, Sheldrake, Helen M, Illingworth, Nicola A, Alandas, Mohammed N, Cooper, Patricia A, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Pors, Klaus, Shnyder, Steve D and Patterson, Laurence H (2013) Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder. Molecular Cancer Therapeutics, 12 (1). pp. 27-37. ISSN 1538-8514

Howell, Lesley A., Bowater, Richard A. ORCID: https://orcid.org/0000-0002-2745-7807, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951, Reszka, Anthony P., Neidle, Stephen and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2012) Synthesis of small molecules targeting multiple DNA structures using click chemistry. ChemMedChem, 7 (5). pp. 792-804. ISSN 1860-7179

Steel, Richard, Cowan, Jonathan, Payerne, Estelle, O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2012) Anti-inflammatory effect of a cell penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Medicinal Chemistry Letters, 3 (5). pp. 407-410. ISSN 1948-5875

Howe, J. D., Payerne, E., Woon, E. C. Y., Marfo, S. A., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 and Gavrilovic, J. (2011) Screening novel small molecules for effects on cancer cell migration. International Journal of Experimental Pathology, 92 (3). A27. ISSN 0959-9673

Howell, Lesley A., Waller, Zoe A. E., Bowater, Richard ORCID: https://orcid.org/0000-0002-2745-7807, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2011) A small molecule that induces assembly of a four way DNA junction at low temperature. Chemical Communications, 47 (29). pp. 8262-8264. ISSN 1359-7345

Pors, Klaus, Loadman, Paul M., Shnyder, Steven D., Sutherland, Mark, Sheldrake, Helen M., Guino, Meritxell, Kiakos, Konstantinos, Hartley, John A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Patterson, Laurence H. (2011) Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity. Chemical Communications, 47 (44). pp. 12062-12064. ISSN 1359-7345

Howell, Lesley, Gulam, Rosul, Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2010) Design and synthesis of threading intercalators to target DNA. Bioorganic & Medicinal Chemistry Letters, 1 (20). pp. 6956-6959. ISSN 1464-3405

Collingwood, S., Lock, R. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2009) Optimizing drugs for local delivery. Drug News & Perspectives, 22 (10). pp. 627-634. ISSN 0214-0934

Howell, Lesley and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2009) Targeting higher-order DNA: Beyond the G-quadruplex. ChemBioChem, 10 (13). pp. 2139-2143. ISSN 1439-7633

Howell, Lesley, Howman, Aaron, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2009) Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic & Medicinal Chemistry Letters, 19 (20). pp. 5880-5883. ISSN 1464-3405

Watanabe, Kenji, Hotta, Kinya, Praseuth, Alex P., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Wang, Clay C. C., Oguri, Hiroki and Oikawa, Hideaki (2009) Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. ChemBioChem, 10 (12). pp. 1965-1968. ISSN 1439-7633

Clark, Ryan C., Lee, Sang Yeul, Hwang, Inkyu, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Boger, Dale L. (2009) Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues. Tetrahedron Letters, 50 (26). pp. 3151-3153.

Shaginian, Alex, Whitby, Landon R., Hong, Sukwon, Hwang, Inkyu, Farooqi, Bilal, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Chen, Jiandong, Vogt, Peter K. and Boger, Dale L. (2009) Design, synthesis, and evaluation of an a-helix mimetic library targeting protein-protein interactions. Journal of the American Chemical Society, 131 (15). pp. 5564-5572.

Clark, Ryan C., Lee, Sang Yeul, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Boger, Dale L. (2009) The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53–MDM2 protein–protein interaction. Natural Product Reports, 26 (4). pp. 465-477. ISSN 1460-4752

Dawson, S., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Hampshire, A., Fox, K. and Malkinson, J. (2009) Solid-phase-based synthesis and biological evaluation of novel chromophore analogues of the bis-intercalator TANDEM. Biopolymers, 92 (4). p. 367. ISSN 0006-3525

Ghosh, Nandita, Sheldrake, Helen M., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Pors, Klaus (2009) Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products. Current Topics in Medicinal Chemistry, 9 (16). pp. 1494-1524. ISSN 1568-0266

Howell, L. A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2009) Targeting the Holliday junction: Design and synthesis of acridine-3/4-carboxamide analogs using click chemistry. Abstracts of Papers of the American Chemical Society, 238. 210-ORGN. ISSN 0065-7727

Hampshire, Andrew J., Rusling, David A., Bryan, Stephanie, Paumier, David, Dawson, Simon J., Malkinson, John P., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Fox, Keith R. (2008) DNA binding by analogues of the bifunctional intercalator TANDEM. Biochemistry, 47 (30). pp. 7900-7906.

Armer, Richard E., Cowley, Phillip and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2008) Recent disclosures of clinical drug candidates. Drug News & Perspectives, 21 (3). pp. 183-188. ISSN 0214-0934

Dawson, S. J., Malkinson, J. P., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 and Gibbons, S. (2008) ORGN 96-Solid-phase-based synthesis and biological evaluation of quinoxaline antibiotics and structural analogs. Abstracts of Papers of the American Chemical Society, 235. 96-ORGN. ISSN 0065-7727

Race, A. D., Pors, K., Shnyder, S. D., Cooper, T. C., Sheldrake, H. M., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Patterson, L. H. and Loadman, P. M. (2008) CYP1A1 activation and pharmacokinetics of a novel chloromethylpyrrollolindoline with potential as a tumour selective prodrug. Ejc Supplements, 6 (12). p. 105. ISSN 1359-6349

Sturla, Shana J., Irwin, John J., Loeppky, Richard N., Mulvihill, Mark J. and Searcey, Marc ORCID: https://orcid.org/0000-0003-2273-8949 (2007) Chemistry in cancer research: A vital partnership. Cancer Research, 67 (14). pp. 6539-6543. ISSN 0008-5472

Brogden, Anna L., Hopcroft, Nicholas H., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Cardin, Christina J. (2007) Ligand bridging of the DNA Holliday junction: Molecular recognition of a stacked-X four-way junction by a small molecule. Angewandte Chemie International Edition, 46 (21). pp. 3850-3854. ISSN 1433-7851

Dawson, Simon, Malkinson, John P., Paumier, David and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2007) Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies. Natural Product Reports, 24 (1). pp. 109-126. ISSN 0265-0568

Woon, Esther C. Y., Arcieri, Mariangela, Wilderspin, Andrew F., Malkinson, John P. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2007) Solid-phase synthesis of chlorofusin analogues. Journal of Organic Chemistry, 72 (14). pp. 5146-5151. ISSN 0022-3263

David-Cordonnier, Marie‐Hélène, Casely-Hayford, Maxwell, Kouach, Mostafa, Briand, Gilbert, Patterson, Laurence H., Bailly, Christian and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). 1658–1661. ISSN 1439-4227

Germain, A. R., Porco, J. A., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 and Woon, E. (2006) Studies towards the synthesis of the p53-MDM2 inhibitor chlorofusin. Abstracts of Papers of the American Chemical Society, 231. 449-ORGN. ISSN 0065-7727

Guino, M., Patterson, L. H. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2006) ORGN 741-Total synthesis of duocarmycin prodrugs. Abstracts of Papers of the American Chemical Society, 232. 741-ORGN. ISSN 0065-7727

Hopcroft, N. H., Brogden, A. L., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 and Cardin, C. J. (2006) X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)(2) molecules by a bis(9-aminoacridine-4-carboxamide) derivative. Nucleic Acids Research, 34 (22). pp. 6663-6672. ISSN 0305-1048

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Neidle, Stephen (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic & Biomolecular Chemistry, 4 (18). pp. 3479-3488. ISSN 1477-0520

Paumier, D., Malkinson, J. P., Hampshire, A. J., Fox, K. R. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2006) ORGN 223-Solid phase-supported synthesis of a water-soluble TANDEM analog. Abstracts of Papers of the American Chemical Society, 232. ISSN 0065-7727

Pors, Klaus, Shnyder, Steven D., Teesdale-Spittle, Paul H., Hartley, John A., Zloh, Mire, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Patterson, Laurence H. (2006) Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: Potential for development of tumor-selective N-oxides. Journal of Medicinal Chemistry, 49 (24). pp. 7013-7023. ISSN 0022-2623

Tsoukala, G., Falconer, R. A. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2006) ORGN 731-Toward the total synthesis of Ipomoeassin B. Abstracts of Papers of the American Chemical Society, 232. 731-ORGN. ISSN 0065-7727

Williams, Robert, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Potter, Barry (2006) Cancer treatments for the new millennium. Drug News & Perspectives, 19 (4). pp. 229-232. ISSN 0214-0934

Woon, E. C. Y. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2006) ORGN 224-Analogs of chlorofusin as potential inhibitors of p53/MDM2 interaction. Abstracts of Papers of the American Chemical Society, 232. 224-ORGN. ISSN 0065-7727

Casely-Hayford, M. A., Kerr, N. O, Smith, E., Gibbons, S. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Antitumour antibiotics with potent activity against multidrug resistant (MDR) Staphylococcus aureus: a new approach to targeting resistant bacteria. Medicinal Chemistry, 1 (6). pp. 619-627. ISSN 1573-4064

Casely-Hayford, M. A., Pors, K., Patterson, L. H., Gerner, C., Neidle, S. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Truncated azinomycin analogues intercalate into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X

Casely-Hayford, M. A., Pors, K., Patterson, L. H. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Design, synthesis and biological evaluation of potential anticancer agents based on the azinomycins. Abstracts of Papers of the American Chemical Society, 229. ISSN 0065-7727

Casely-Hayford, Maxwell A., Pors, Klaus, James, Colin H., Patterson, Laurence H., Hartley, John A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Design and synthesis of a DNA-crosslinking azinomycin analogue. Organic & Biomolecular Chemistry, 3 (19). pp. 3585-3589. ISSN 1477-0520

David-Cordonnier, M. H., Casely-Hayford, M., Patterson, L. H., Bailly, C. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Influence of the stereoisomeric position of azinomycin epoxide on DNA binding and sequence selectivity. Clinical Cancer Research, 11 (24). 9013S-9013S. ISSN 1078-0432

Kerr, N. O., Grewel, S. S., Martin, B. G. O., Karu, K., Patterson, L. H. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Design and synthesis of bio-oxidatively activated prodrugs based upon the duocarmycins: Routes to Boc-CI and CI-MI prodrugs. Abstracts of Papers of the American Chemical Society, 229. 413-MEDI. ISSN 0065-7727

Malkinson, J. P., Anim, M. K., Zloh, M., Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Hampshire, A. J. and Fox, K. R. (2005) Efficient solid-phase-based total synthesis of the bisintercalator TANDEM. Journal of Organic Chemistry, 70 (19). pp. 7654-7661. ISSN 0022-3263

Pors, Klaus, Plumb, Jane A., Brown, Robert, Teesdale-Spittle, Paul, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Smith, Paul J. and Patterson, Laurence H. (2005) Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells. Journal of Medicinal Chemistry, 48 (21). pp. 6690-6695. ISSN 0022-2623

Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Karu, K., Grewal, S. S., Kerr, N. O., Griffith, W. and Patterson, L. H. (2005) Prodrug analogs of the duocarmycins activated by CYP-oxidation. Abstracts of Papers of the American Chemical Society, 229. 414-MEDI. ISSN 0065-7727

Searcey, M ORCID: https://orcid.org/0000-0003-2273-8949 and Patterson, LH (2004) Resistance in cancer: A target for drug discovery. Current Medicinal Chemistry - Anti-Cancer Agents, 4 (5). pp. 457-460. ISSN 1568-0118

Malkinson, John P., Zloh, Mire, Kadom, Mohanad, Errington, Rachel, Smith, Paul J. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2003) Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions. Organic Letters, 5 (26). pp. 5051-5054. ISSN 1523-7060

Malkinson, J. P. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2003) Solid-phase synthesis of des-N-tetramethyltriostin a (TANDEM). Biopolymers, 71 (3). P280. ISSN 0006-3525

Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Malkinson, J. P. and Kadom, M. (2003) Towards the total synthesis of chlorofusin: Solid phase synthesis of the cyclic peptide. Abstracts of Papers of the American Chemical Society, 226. 708-ORGN. ISSN 0065-7727

Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Grewal, Sukhwant S., Madeo, Fiorenza and Tsoungas, Petros G. (2003) A mild procedure for the production of secondary amines from oximes and benzisoxazoles. Tetrahedron Letters, 44 (35). pp. 6745-6747. ISSN 0040-4039

Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2002) Duocarmycins - Natures prodrugs? Current Pharmaceutical Design, 8 (15). pp. 1375-1389. ISSN 1381-6128

Tsoungas, Petros G. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2001) A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators. Tetrahedron Letters, 42 (37). pp. 6589-6592. ISSN 0040-4039

Boger, Dale L., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Tse, Winston C. and Jin, Qing (2000) Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 495-498. ISSN 0960-894X

Boger, Dale L., Aquila, Brian M., Tse, Winston C. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2000) Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain. Tetrahedron Letters, 41 (49). pp. 9493-9498. ISSN 0040-4039

Boger, Dale L., Santillan, Alejandro, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Brunette, Steven R., Wolkenberg, Scott E., Hedrick, Michael P. and Jin, Qing (2000) Synthesis and evaluation of 1,2,8,8a-tetrahydrocyclopropa c pyrrolo 3,2-e indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: Impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis. Journal of Organic Chemistry, 65 (13). pp. 4101-4111. ISSN 0022-3263

Boger, Dale L., Ledeboer, Mark W., Kume, Masaharu, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Jin, Qing (1999) Total synthesis and comparative evaluation of luzopeptin A-C and quinoxapeptin A-C. Journal of the American Chemical Society, 121 (49). pp. 11375-11383. ISSN 0002-7863

Boger, Dale L., Santillán, Alejandro, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Jin, Qing (1999) Synthesis and evaluation of duocarmycin and CC-1065 analogues containing modifications in the subunit linking amide. Journal of Organic Chemistry, 64 (14). pp. 5241-5244. ISSN 0022-3263

McClean, S, Costelloe, C, Denny, W A, Searcey, M ORCID: https://orcid.org/0000-0003-2273-8949 and Wakelin, L P (1999) Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards. Anti-Cancer Drug Design, 14 (3). pp. 187-204. ISSN 0266-9536

Boger, Dale L., Boyce, Christopher W., Garbaccio, Robert M., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Jin, Qing (1999) CBI prodrug analogs of CC-1065 and the duocarmycins. Synthesis-Stuttgart, 1999 (S1). pp. 1505-1509. ISSN 0039-7881

Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, McClean, S, Madden, B, McGown, A T and Wakelin, L P (1998) Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anti-Cancer Drug Design, 13 (8). pp. 837-855. ISSN 0266-9536

Boger, Dale L., Santillán, Alejandro, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Jin, Qing (1998) Critical role of the linking amide in CC-1065 and the duocarmycins:Implications on the source of DNA alkylation catalysis. Journal of the American Chemical Society, 120 (45). pp. 11554-11557. ISSN 0002-7863

Boger, Dale L. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (1998) The first synthesis of a daphnane diterpene:The enantiocontrolled total synthesis of (+)-resiniferatoxin. Chemtracts, 11 (9). pp. 647-651. ISSN 1431-9268

Boger, Dale L., Boyce, Christopher W., Garbaccio, Robert M. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (1998) Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride. Tetrahedron Letters, 39 (16). pp. 2227-2230. ISSN 0040-4039

Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, McClean, Siobhán, Madden, Bernie and Wakelin, Laurence P. G. (1997) Bleomycin mimics. Design and synthesis of an acridine derivative which cleaves DNA in a sequence-neutral manner. Journal of the Chemical Society. Perkin Transactions 2 (3). pp. 523-532. ISSN 0300-9580

Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Martin, P. Noel, Howarth, Nicola M., Madden, Bernie and Wakelin, Laurence P. G. (1996) DNA threading agents: Effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides. Bioorganic and Medicinal Chemistry Letters, 6 (15). pp. 1831-1836. ISSN 0960-894X

Gallacher, Gerard, Jackson, Caroline S., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Goel, Rajiv, Mellor, Geoffrey W., Smith, Carmen Z. and Brocklehurst, Keith (1993) Catalytic antibody activity elicited by active immunisation. Evidence for natural variation involving preferential stabilization of the transition state. European Journal of Biochemistry, 214 (1). pp. 197-207. ISSN 0014-2956

Gallacher, G, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Jackson, C S and Brocklehurst, K (1992) Polyclonal antibody-catalysed amide hydrolysis. Biochemical Journal, 284 (3). pp. 675-860. ISSN 0264-6021

Gallacher, G, Jackson, C S, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Badman, G T, Goel, R, Topham, C M, Mellor, G W and Brocklehurst, K (1991) A polyclonal antibody preparation with Michaelian catalytic properties. Biochemical Journal, 279 (3). pp. 871-881. ISSN 0264-6021

Gallacher, Gerard, Jackson, Caroline S., Topham, Christopher M., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Turner, Benjamin C., Badman, Geoffrey T. and Brocklehurst, Keith (1990) Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate. Biochemical Society Transactions, 18 (4). pp. 600-601. ISSN 0300-5127

Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949, Pye, P. L. and Lee, J. B. (1989) Improved syntheses of n-substituted nitroimidazoles. Synthetic Communications, 19 (7-8). pp. 1309-1315. ISSN 0039-7911

Book Section

Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M D and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2019) Duocarmycins as Antibody–Drug Conjugate (ADC) Payloads. In: Cytotoxic Payloads for Antibody-Drug Conjugates. Royal Society of Chemistry. ISBN 978-1-78801-077-1

Casely-Hayford, Maxwell and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2002) The Azinomycins. Discovery, Synthesis and DNA-Binding Studies. In: DNA and RNA Binders. Wiley, pp. 676-696. ISBN 3527305955

Patent

Stephenson, Michael J. (2017) Synthesis of duocarmycin analogues. US9765077B2.