Truncated azinomycin analogues intercalate into DNA

Casely-Hayford, M. A., Pors, K., Patterson, L. H., Gerner, C., Neidle, S. and Searcey, M. (2005) Truncated azinomycin analogues intercalate into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X

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Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 13 Jun 2011 13:35
Last Modified: 21 Apr 2020 20:00
URI: https://ueaeprints.uea.ac.uk/id/eprint/32137
DOI: 10.1016/j.bmcl.2004.11.037

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