Truncated azinomycin analogues intercalate into DNA

Casely-Hayford, M. A., Pors, K., Patterson, L. H., Gerner, C., Neidle, S. and Searcey, M. ORCID: https://orcid.org/0000-0003-2273-8949 (2005) Truncated azinomycin analogues intercalate into DNA. Bioorganic & Medicinal Chemistry Letters, 15 (3). pp. 653-656. ISSN 0960-894X

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Abstract

The design and synthesis of a potentially more therapeutically-viable azinomycin analogue 4 based upon 3 has been completed. It involved coupling of a piperidine mustard to the acid chloride of the azinomycin chromophore. Both the designed azinomycin analogue 4 and the natural product 3 bind to DNA and cause unwinding, supporting an intercalative mode of binding. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 13:35
Last Modified:	24 Sep 2024 09:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32137
DOI:	10.1016/j.bmcl.2004.11.037

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