A small molecule that induces assembly of a four way DNA junction at low temperature

Howell, Lesley A., Waller, Zoe A. E., Bowater, Richard ORCID: https://orcid.org/0000-0002-2745-7807, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2011) A small molecule that induces assembly of a four way DNA junction at low temperature. Chemical Communications, 47 (29). pp. 8262-8264. ISSN 1359-7345

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Abstract

Small molecules that induce the formation of higher order DNA structures have potential therapeutic and nanotechnology applications. Screening of a click library has identified the first compound to induce the formation of a Holliday junction structure at room temperature without the need for a high temperature annealing step.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Biosciences Teaching and Education Research Faculty of Science > Research Groups > Molecular Microbiology Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Molecular and Tissue Pharmacology (former - to 2025) Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Pharmacology and Biological Chemistry Faculty of Science > Research Groups > Synthetic and Medicinal Chemistry
Depositing User:	Users 2731 not found.
Date Deposited:	01 Aug 2011 12:26
Last Modified:	18 Jun 2026 14:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/34317
DOI:	10.1039/c1cc12922h

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