A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity

Cartwright, Oliver Charles, Beekman, Andrew Michael ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2020) A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity. Bioconjugate Chemistry, 31 (7). 1745–1749. ISSN 1043-1802

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Abstract

Solid phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumour cell lines.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy Faculty of Science > School of Chemistry
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	17 Jun 2020 00:12
Last Modified:	21 Apr 2023 00:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75612
DOI:	10.1021/acs.bioconjchem.0c00282

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