A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity
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Cartwright, Oliver Charles, Beekman, Andrew Michael, Cominetti, Marco M D, Russell, David A and Searcey, Mark (2020) A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity. Bioconjugate Chemistry, 31 (7). 1745–1749. ISSN 1043-1802
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Abstract
Solid phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumour cell lines.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Science > School of Chemistry |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 17 Jun 2020 00:12 |
Last Modified: | 28 Jul 2020 00:13 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/75612 |
DOI: | 10.1021/acs.bioconjchem.0c00282 |
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