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Cartwright, Oliver Charles, Beekman, Andrew Michael 
ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949
(2020)
A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity.
Bioconjugate Chemistry, 31 (7).
1745–1749.
ISSN 1043-1802
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Abstract
Solid phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumour cell lines.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Jun 2020 00:12 |
| Last Modified: | 30 Sep 2024 00:18 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/75612 |
| DOI: | 10.1021/acs.bioconjchem.0c00282 |
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