Junctions in DNA: underexplored targets for therapeutic intervention

Ivens, Eleanor, Cominetti, Marco M. D. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2022) Junctions in DNA: underexplored targets for therapeutic intervention. Bioorganic & Medicinal Chemistry, 69. ISSN 0968-0896

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Abstract

DNA has been a key target for cancer therapy, with a range of compounds able to bind and either impair its processing or induce damage. Targeting DNA with small molecules in a truly sequence specific way, to impair gene specific processes, remains out of reach. The ability of DNA to assume different structures from the classical double helix allows access to more specific ligand binding modes and, potentially, to new avenues of treatment. In this review, we illustrate the small molecules that have been reported to bind to three- and four-way junctions.

Item Type: Article
Uncontrolled Keywords: four-way junction,holliday junction,three-way junction,drug discovery,molecular medicine,molecular biology,biochemistry,clinical biochemistry,pharmaceutical science,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3002
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 28 Jun 2022 09:30
Last Modified: 12 Aug 2022 04:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/85827
DOI: 10.1016/j.bmc.2022.116897

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