Tools
Tools
Ivens, Eleanor, Cominetti, Marco M. D. and Searcey, Mark 
ORCID: https://orcid.org/0000-0003-2273-8949
(2022)
Junctions in DNA: underexplored targets for therapeutic intervention.
Bioorganic & Medicinal Chemistry, 69.
ISSN 0968-0896
Preview |
PDF (1-s2.0-S0968089622002905-main)
- Published Version
Available under License Creative Commons Attribution. Download (11MB) | Preview |
Abstract
DNA has been a key target for cancer therapy, with a range of compounds able to bind and either impair its processing or induce damage. Targeting DNA with small molecules in a truly sequence specific way, to impair gene specific processes, remains out of reach. The ability of DNA to assume different structures from the classical double helix allows access to more specific ligand binding modes and, potentially, to new avenues of treatment. In this review, we illustrate the small molecules that have been reported to bind to three- and four-way junctions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | four-way junction,holliday junction,three-way junction,drug discovery,molecular medicine,molecular biology,biochemistry,clinical biochemistry,pharmaceutical science,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3002 |
| Faculty \ School: | Faculty of Science > School of Chemistry Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 28 Jun 2022 09:30 |
| Last Modified: | 21 Apr 2023 02:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/85827 |
| DOI: | 10.1016/j.bmc.2022.116897 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |