Resistance in cancer: A target for drug discovery

Searcey, M and Patterson, LH (2004) Resistance in cancer: A target for drug discovery. Current Medicinal Chemistry - Anti-Cancer Agents, 4 (5). pp. 457-460. ISSN 1568-0118

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Abstract

Resistance remains a major problem in the clinical utility of cancer chemotherapy. However, it also represents a tumour cell phenotype that is in many ways different, and thus distinguishable, from the majority of normal cells. Two approaches to the targeting of resistant cells are described involving intratumoral P450 expression, mechanisms of drug-efflux and defective DNA repair. It is suggested that the view of the solid tumour as a complex organ rather than a collection of individual cells will inform future drug development and both overcome and target multiple resistance mechanisms.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 09 Jun 2011 11:45
Last Modified: 31 Oct 2019 14:01
URI: https://ueaeprints.uea.ac.uk/id/eprint/32092
DOI:

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