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Searcey, M 
ORCID: https://orcid.org/0000-0003-2273-8949 and Patterson, LH
(2004)
Resistance in cancer: A target for drug discovery.
Current Medicinal Chemistry - Anti-Cancer Agents, 4 (5).
pp. 457-460.
ISSN 1568-0118
Abstract
Resistance remains a major problem in the clinical utility of cancer chemotherapy. However, it also represents a tumour cell phenotype that is in many ways different, and thus distinguishable, from the majority of normal cells. Two approaches to the targeting of resistant cells are described involving intratumoral P450 expression, mechanisms of drug-efflux and defective DNA repair. It is suggested that the view of the solid tumour as a complex organ rather than a collection of individual cells will inform future drug development and both overcome and target multiple resistance mechanisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Rachel Smith |
| Date Deposited: | 09 Jun 2011 11:45 |
| Last Modified: | 24 Sep 2024 10:07 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/32092 |
| DOI: |
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