Active targeting of gold nanoparticles as cancer therapeutics

Goddard, Zoë Rachael, Marin, Maria J., Russell, David A. and Searcey, Mark (2020) Active targeting of gold nanoparticles as cancer therapeutics. Chemical Society Reviews, 49 (23). pp. 8774-8789. ISSN 0306-0012

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Abstract

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability makes them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 20 Oct 2020 23:57
Last Modified: 25 Jul 2021 00:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/77372
DOI: 10.1039/d0cs01121e

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