Active targeting of gold nanoparticles as cancer therapeutics

Goddard, Zoë Rachael ORCID:, Marin, Maria J. ORCID:, Russell, David A. and Searcey, Mark ORCID: (2020) Active targeting of gold nanoparticles as cancer therapeutics. Chemical Society Reviews, 49 (23). pp. 8774-8789. ISSN 0306-0012

[thumbnail of Published_Version]
PDF (Published_Version) - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (3MB) | Preview


Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability makes them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. Here, we review the recent advances in targeted-AuNPs for the treatment of cancer, with a particular focus on these classes of targeting ligands. We highlight the benefits and potential drawbacks of each ligand class and propose directions in which the field could grow.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 20 Oct 2020 23:57
Last Modified: 21 Apr 2023 00:49
DOI: 10.1039/d0cs01121e


Downloads per month over past year

Actions (login required)

View Item View Item