A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Tsoungas, Petros G. and Searcey, Mark (2001) A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators. Tetrahedron Letters, 42 (37). pp. 6589-6592. ISSN 0040-4039

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Abstract

2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	agents,nitrite,conversion,aryl halides
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 14:31
Last Modified:	28 Mar 2025 04:54
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32128
DOI:	10.1016/S0040-4039(01)01302-8

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