A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators

Tsoungas, Petros G. and Searcey, Mark (2001) A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators. Tetrahedron Letters, 42 (37). pp. 6589-6592. ISSN 0040-4039

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Abstract

2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine. (C) 2001 Elsevier Science Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: agents,nitrite,conversion,aryl halides
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 13 Jun 2011 14:31
Last Modified: 21 Apr 2020 21:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/32128
DOI: 10.1016/S0040-4039(01)01302-8

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