Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide

David-Cordonnier, Marie‐Hélène, Casely-Hayford, Maxwell, Kouach, Mostafa, Briand, Gilbert, Patterson, Laurence H., Bailly, Christian and Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). 1658–1661. ISSN 1439-4227

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Abstract

Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).

Item Type:	Article
Uncontrolled Keywords:	antitumor agents,azinomycin,depurination,dna cleavage,natural products
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 12:01
Last Modified:	28 Mar 2025 03:59
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32144
DOI:	10.1002/cbic.200600244

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