Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide
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David-Cordonnier, Marie‐Hélène, Casely-Hayford, Maxwell, Kouach, Mostafa, Briand, Gilbert, Patterson, Laurence H., Bailly, Christian and Searcey, Mark (2006) Stereoselectivity, sequence specificity and mechanism of action of the azinomycin epoxide. ChemBioChem, 7 (11). 1658–1661. ISSN 1439-4227
Full text not available from this repository. (Request a copy)Abstract
Not like the rest. In this study we show that the four diastereomers of the azinomycin epoxide (1) have different sequence selectivities, while the natural product appears to exert its effects through reversible N7 alkylation of guanine followed by irreversible depurination (see scheme).
Item Type: | Article |
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Uncontrolled Keywords: | antitumor agents,azinomycin,depurination,dna cleavage,natural products |
Faculty \ School: | Faculty of Science > School of Pharmacy |
Depositing User: | Rachel Smith |
Date Deposited: | 13 Jun 2011 12:01 |
Last Modified: | 28 Apr 2022 00:13 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/32144 |
DOI: | 10.1002/cbic.200600244 |
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