Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity

Boger, Dale L., Searcey, Mark, Tse, Winston C. and Jin, Qing (2000) Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity. Bioorganic & Medicinal Chemistry Letters, 10 (5). pp. 495-498. ISSN 0960-894X

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Abstract

The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described. (C) 2000 Elsevier Science Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	amide,cc-1065,pyrindamycin-a,streptomyces sp,binding,catalysis,analogs,dna,subunits,antibiotics
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 14:30
Last Modified:	28 Mar 2025 04:55
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32127
DOI:	10.1016/S0960-894X(00)00042-1

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