Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Howell, Lesley, Howman, Aaron, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2009) Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic & Medicinal Chemistry Letters, 19 (20). pp. 5880-5883. ISSN 1464-3405

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Abstract

A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Depositing User:	Rachel Smith
Date Deposited:	17 Mar 2011 10:58
Last Modified:	12 Jan 2023 13:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26453
DOI:	10.1016/j.bmcl.2009.08.070

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