Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry

Howell, Lesley, Howman, Aaron, O'Connell, Maria, Mueller, Anja and Searcey, Mark (2009) Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic & Medicinal Chemistry Letters, 19 (20). pp. 5880-5883. ISSN 1464-3405

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Abstract

A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 17 Mar 2011 10:58
Last Modified: 31 Oct 2019 13:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/26453
DOI: 10.1016/j.bmcl.2009.08.070

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