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Clark, Ryan C., Lee, Sang Yeul, Hwang, Inkyu, Searcey, Mark 
ORCID: https://orcid.org/0000-0003-2273-8949 and Boger, Dale L.
(2009)
Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues.
Tetrahedron Letters, 50 (26).
pp. 3151-3153.
Abstract
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Rachel Smith |
| Date Deposited: | 17 Mar 2011 14:19 |
| Last Modified: | 06 Jan 2023 10:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/26559 |
| DOI: | 10.1016/j.tetlet.2009.01.081 |
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