Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

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Clark, Ryan C., Lee, Sang Yeul, Hwang, Inkyu, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Boger, Dale L. (2009) Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues. Tetrahedron Letters, 50 (26). pp. 3151-3153.

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Abstract

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 17 Mar 2011 14:19
Last Modified: 06 Jan 2023 10:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/26559
DOI: 10.1016/j.tetlet.2009.01.081

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