Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Boger, Dale L., Aquila, Brian M., Tse, Winston C. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2000) Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain. Tetrahedron Letters, 41 (49). pp. 9493-9498. ISSN 0040-4039

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Abstract

The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

Item Type:	Article
Uncontrolled Keywords:	activation,acid,binding,rna,preorganization,degradation,antibiotics,selective dna cleavage,neocarzinostatin,mechanisms
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 14:20
Last Modified:	18 Jun 2026 15:57
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32125
DOI:	10.1016/S0040-4039(00)01633-6

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