Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain

Boger, Dale L., Aquila, Brian M., Tse, Winston C. and Searcey, Mark (2000) Synthesis and evaluation of a novel bleomycin A(2) analogue: continuing assessment of the linker domain. Tetrahedron Letters, 41 (49). pp. 9493-9498. ISSN 0040-4039

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Abstract

The synthesis and evaluation of a bithiazole ester analogue of deglycobleomycin A(2) that addresses the importance of the bithiazole-L-threonine amide for efficient DNA cleavage is described. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

Item Type: Article
Uncontrolled Keywords: activation,acid,binding,rna,preorganization,degradation,antibiotics,selective dna cleavage,neocarzinostatin,mechanisms
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 13 Jun 2011 14:20
Last Modified: 31 Oct 2019 14:08
URI: https://ueaeprints.uea.ac.uk/id/eprint/32125
DOI: 10.1016/S0040-4039(00)01633-6

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