Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Goddard, Zoe, Beekman, Andrew, Cominetti, Marco, Chambrier, Isabelle, Cook, Michael J., Marin, Maria J., Russell, David and Searcey, Mark (2020) Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers. RSC Medicinal Chemistry. ISSN 2632-8682

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Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science > School of Chemistry
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2020 00:49
Last Modified: 24 Jan 2021 00:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/77822
DOI: 10.1039/D0MD00284D

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