Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Goddard, Zoë Rachael ORCID: https://orcid.org/0000-0002-7900-1553, Beekman, Andrew Michael ORCID: https://orcid.org/0000-0002-3056-6406, Cominetti, Marco M. D., O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951, Chambrier, Isabelle, Cook, Michael J., Marin, Maria J. ORCID: https://orcid.org/0000-0001-8021-5498, Russell, David A. and Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 (2021) Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers. RSC Medicinal Chemistry, 12 (2). pp. 288-292. ISSN 2632-8682

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Abstract

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Chemistry (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Depositing User:	LivePure Connector
Date Deposited:	27 Nov 2020 00:49
Last Modified:	23 Oct 2024 23:55
URI:	https://ueaeprints.uea.ac.uk/id/eprint/77822
DOI:	10.1039/D0MD00284D

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