Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark ORCID: and Neidle, Stephen (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic & Biomolecular Chemistry, 4 (18). pp. 3479-3488. ISSN 1477-0520

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A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017)
Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User: Rachel Smith
Date Deposited: 13 Jun 2011 12:21
Last Modified: 24 Oct 2022 01:57
DOI: 10.1039/b607707b

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