Synthesis of distamycin A polyamides targeting G-quadruplex DNA

Moore, Michael J. B., Cuenca, Francisco, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Neidle, Stephen (2006) Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Organic & Biomolecular Chemistry, 4 (18). pp. 3479-3488. ISSN 1477-0520

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Abstract

A number of amide-linked oligopyrroles based on distamycin molecules have been synthesized by solid-state methods, and their interactions with a human intramolecular G-quadruplex have been measured by a melting procedure. Several of these molecules show an enhanced ratio of quadruplex vs. duplex DNA binding compared to distamycin itself, including one with a 2,5-disubstituted pyrrole group. Quadruplex affinity increases with the number of pyrrole groups, and it is suggested that this is consistent with a mixed groove/G-quartet stacking binding mode.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User:	Rachel Smith
Date Deposited:	13 Jun 2011 12:21
Last Modified:	24 Sep 2024 09:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/32148
DOI:	10.1039/b607707b

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