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Williams, Morwen RM, Bertrand, Benoît, Fernandez-Cestau, Julio, Waller, Zoë AE, O'Connell, Maria A 
ORCID: https://orcid.org/0000-0002-0267-0951, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Bochmann, Manfred ORCID: https://orcid.org/0000-0001-7736-5428
(2018)
Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations.
Dalton Transactions, 47 (38).
pp. 13523-13534.
ISSN 1477-9226
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Abstract
(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.
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