Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

Williams, Morwen RM, Bertrand, Benoît, Fernandez-Cestau, Julio, Waller, Zoë AE, O'Connell, Maria A, Searcey, Mark and Bochmann, Manfred (2018) Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations. Dalton Transactions, 47 (38). pp. 13523-13534. ISSN 1477-9226

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Abstract

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology (former - to 2025) Faculty of Science > Research Groups > Chemistry of Light and Energy (former - to 2025) Faculty of Science > Research Groups > Chemistry of Materials and Catalysis (former - to 2025) Faculty of Science > Research Groups > Pharmacology and Biological Chemistry Faculty of Science > Research Groups > Synthetic and Medicinal Chemistry
Depositing User:	LivePure Connector
Date Deposited:	24 Sep 2018 14:30
Last Modified:	06 Feb 2026 08:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/68336
DOI:	10.1039/C8DT02507J

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