Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli

Watanabe, Kenji, Hotta, Kinya, Praseuth, Alex P., Searcey, Mark, Wang, Clay C. C., Oguri, Hiroki and Oikawa, Hideaki (2009) Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia coli. ChemBioChem, 10 (12). pp. 1965-1968. ISSN 1439-7633

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Abstract

Drugs from bugs . We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 17 Mar 2011 14:18
Last Modified: 31 Oct 2019 13:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/26561
DOI: 10.1002/cbic.200900260

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