Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli

Watanabe, Kenji, Hotta, Kinya, Praseuth, Alex P., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Wang, Clay C. C., Oguri, Hiroki and Oikawa, Hideaki (2009) Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. ChemBioChem, 10 (12). pp. 1965-1968. ISSN 1439-7633

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Abstract

Drugs from bugs . We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Medicinal Chemistry (former - to 2017) Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Synthetic and Medicinal Chemistry
Depositing User:	Rachel Smith
Date Deposited:	17 Mar 2011 14:18
Last Modified:	18 Jun 2026 15:04
URI:	https://ueaeprints.uea.ac.uk/id/eprint/26561
DOI:	10.1002/cbic.200900260

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