Watanabe, Kenji, Hotta, Kinya, Praseuth, Alex P., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949, Wang, Clay C. C., Oguri, Hiroki and Oikawa, Hideaki
(2009)
Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli.
ChemBioChem, 10 (12).
pp. 1965-1968.
ISSN 1439-7633
Abstract
Drugs from bugs . We have successfully expanded the scope of our E. coli-based total biosynthesis of natural products and their analogues by rationally engineering the echinomycin biosynthesis pathway for the production of a synthetic analogue of triostin A, TANDEM; this demonstrates the amenability of the biosynthesis enzymes and E. coli towards further engineering.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy |
Depositing User: | Rachel Smith |
Date Deposited: | 17 Mar 2011 14:18 |
Last Modified: | 12 Jan 2023 12:30 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/26561 |
DOI: | 10.1002/cbic.200900260 |
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