Items where Author is "O'Connell, Maria"

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Number of items: 72.

Article

M. M. D. Cominetti, Marco, Goddard, Zoë R., Howman, Chloe E., O'Connell, Maria A. and Searcey, Mark (2021) Amino DSA analogues as payloads for antibody-drug conjugates with multiple sites for conjugation. Initial studies and solid phase synthesis. Tetrahedron Letters, 72. ISSN 0040-4039

Wright, Mark A., O'Connell, Maria A. and Wright, Joseph A. (2021) Ruthenium carbamoyl complexes: coordination chemistry and CO release. Inorganica Chimica Acta, 520. ISSN 0020-1693

Goddard, Zoë Rachael, Beekman, Andrew Michael, Cominetti, Marco M. D., O'Connell, Maria A., Chambrier, Isabelle, Cook, Michael J., Marin, Maria J., Russell, David A. and Searcey, Mark (2021) Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers. RSC Medicinal Chemistry, 12 (2). pp. 288-292. ISSN 2632-8682

Wright, Mark, Wooldridge, Tyler, O'Connell, Maria and Wright, Joseph (2020) Ferracyclic carbonyl complexes as anti-inflammatory agents. Chemical Communications, 56 (31). pp. 4300-4303. ISSN 1359-7345

Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo Alvarez, Jesus and Searcey, Mark (2019) Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design. Chemical Science, 10 (16). pp. 4502-4508. ISSN 2041-6520

Williams, Morwen, Bertrand, Benoît, Hughes, David L., Waller, Zoe Ann Ella, Schmidt, Claudia, Ott, Ingo, O'Connell, Maria Anne, Searcey, Mark and Bochmann, Manfred (2018) Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies. Metallomics, 10 (11). pp. 1655-1666. ISSN 1756-5901

Williams, Morwen RM, Bertrand, Benoît, Fernandez-Cestau, Julio, Waller, Zoë AE, O'Connell, Maria A, Searcey, Mark and Bochmann, Manfred (2018) Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations. Dalton Transactions, 47 (38). pp. 13523-13534. ISSN 1477-9226

Steel, Richard J., O'Connell, Maria A. and Searcey, Mark (2018) Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction. Bioorganic & Medicinal Chemistry Letters, 28 (16). pp. 2728-2731. ISSN 0960-894X

Warner, Emily F, Rodriguez-Ramiro, Ildefonso, O'Connell, Maria A and Kay, Colin D (2018) Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells. Molecules, 23 (4). ISSN 1420-3049

Benoît, Bertrand, O'Connell, Maria A., Waller, Zoe A. E. and Bochmann, Manfred (2018) A gold(III) pincer ligand scaffold for the synthesis of binuclear and bioconjugated complexes: synthesis and anticancer potential. Chemistry - A European Journal, 24 (14). 3613–3622. ISSN 0947-6539

Bulman Page, Philip C., Goodyear, Ross L., Horton, Alexandra E., Chan, Yohan, Karim, Rehana, O'Connell, Maria A., Hamilton, Christopher, Slawin, Alexandra M. Z., Buckley, Benjamin R. and Allin, Steven M. (2017) Formal Total Synthesis of (+)-C9-Deoxyomuralide from l-Leucine Using a Double Sacrificial Chirality Transfer Approach. The Journal of Organic Chemistry, 82 (23). 12209–12223. ISSN 0022-3263

Bertrand, Benoît, Romanov, Alexander S, Brooks, Mark, Schmidt, Claudia, Ott, Ingo, O'Connell, Maria Anne and Bochmann, Manfred (2017) Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals. Dalton Transactions, 46. pp. 15875-15887. ISSN 1477-9226

Williams, Morwen, Green, Adam I, Fernandez-Cestau, Julio, Hughes, David L, O'Connell, Maria Anne, Searcey, Mark, Bertrand, Benoit and Bochmann, Manfred (2017) (C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties. Dalton Transactions, 46 (39). 13397–13408. ISSN 1477-9226

Warner, Emily F., Smith, Michael J., Zhang, Qingzhi, Raheem, K. Saki, O'Hagan, David, O'Connell, Maria A. and Kay, Colin D. (2017) Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Molecular Nutrition & Food Research, 61 (9). ISSN 1613-4125

Beekman, Andrew Michael, O'Connell, Maria Anne and Howell, Lesley Ann (2017) Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1. Angewandte Chemie International Edition, 56 (35). 10446–10450. ISSN 1433-7851

Reed, James, Stephenson, Michael J, Miettinen, Karel, Brouwer, Bastiaan, Leveau, Aymeric, Brett, Paul, Goss, Rebecca J M, Goossens, Alain, O'Connell, Maria A and Osbourn, Anne (2017) A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules. Metabolic Engineering, 42. 185–193. ISSN 1096-7176

Bertrand, Benoît, Fernandez-Cestau, Julio, Angulo, Jesus, Cominetti, Marco M.D., Waller, Zoe A.E., Searcey, Mark, O'Connell, Maria A. and Bochmann, Manfred (2017) Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties. Inorganic Chemistry, 56 (10). 5728–5740. ISSN 0020-1669

Beekman, Andrew M., O'Connell, Maria A. and Howell, Lesley A. (2016) Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1). ChemMedChem, 11 (8). 840–844. ISSN 1860-7179

Warner, Emily F, Zhang, Qingzhi, Raheem, K Saki, O'Hagan, David, O'Connell, Maria A and Kay, Colin D (2016) Common phenolic metabolites of flavonoids, but not their unmetabolized precursors, reduce the secretion of vascular cellular adhesion molecules by human endothelial cells. Journal of Nutrition, 146 (3). pp. 465-473. ISSN 0022-3166

Codoni, Doroty, Cowan, Jonathan, Bradley, Jenna, O'Connell, Maria, McAuley, William and Qi, Sheng (2015) Disc-shaped polyoxyethylene glycol glycerides gel nanoparticles as novel protein delivery vehicles. International Journal of Pharmaceutics, 496 (2). pp. 1015-1025. ISSN 0378-5173

Cominetti, Marco, Goffin, Sarah, Raffel, Ewan, Turner, Kerrie, Ramoutar, Jordann, O'Connell, Maria, Howell, Lesley and Searcey, Mark (2015) Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin. Bioorganic & Medicinal Chemistry Letters, 25 (21). pp. 4878-4880. ISSN 0960-894X

Stephenson, Michael, Howell, Lesley, O'Connell, Maria, Fox, Keith R., Adcock, Claire, Kingston, Jenny, Sheldrake, Helen, Pors, Klaus, Collingwood, Stephen P. and Searcey, Mark (2015) Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity. The Journal of Organic Chemistry, 80 (19). 9454–9467. ISSN 0022-3263

Di Gesso, Jessica, Kerr, Jason, Zhang, Qingzhi, Raheem, Saki, Krishna Yalamanchili, Sai, O'Hagan, David, Kay, Colin and O'Connell, Maria (2015) Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes. Molecular Nutrition & Food Research, 59 (6). 1143–1154. ISSN 1613-4125

Waller, Zoë A E, Howell, Lesley A, Macdonald, Colin J, O'Connell, Maria A and Searcey, Mark (2014) Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Biochemical and Biophysical Research Communications, 447 (1). pp. 128-32. ISSN 0006-291X

Tortorici, Marcello, Borrello, Maria Teresa, Tardugno, Maria, Chiarelli, Laurent R, Pilotto, Simona, Ciossani, Giuseppe, Vellore, Nadeem A, Bailey, Sarah G, Cowan, Jonathan, O'Connell, Maria, Crabb, Simon J, Packham, Graham, Mai, Antonello, Baron, Riccardo, Ganesan, A and Mattevi, Andrea (2013) Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS Chemical Biology, 8 (8). pp. 1677-1682. ISSN 1554-8937

Howell, Lesley A., Bowater, Richard A., O'Connell, Maria A., Reszka, Anthony P., Neidle, Stephen and Searcey, Mark (2012) Synthesis of Small Molecules Targeting Multiple DNA Structures using Click Chemistry. ChemMedChem, 7 (5). pp. 792-804. ISSN 1860-7179

Norton, R and O'Connell, MA (2012) Vitamin D: Potential in the prevention and treatment of lung cancer. Anticancer Research, 32. pp. 211-222. ISSN 1791-7530

Steel, Richard, Cowan, Jonathan, Payerne, Estelle, O'Connell, Maria A. and Searcey, Mark (2012) Anti-inflammatory effect of a cell penetrating peptide targeting the Nrf2/Keap1 interaction. ACS Medicinal Chemistry Letters, 3 (5). pp. 407-410. ISSN 1948-5875

Norton, R, Sexton, DW, Clark, IM, Wilson, AM, Hughes, DA and O'Connell, MA (2011) Immunomodulatory effects of 1, 25 (OH)2 D-3 in normal and transformed human lung epithelium. Anticancer Research, 31 (4). p. 1499. ISSN 0250-7005

Howell, LA, Waller, Z.A.E., Bowater, RP, O'Connell, M and Searcey, M (2011) A small molecule that induces assembly of a four way DNA junction at low temperature. Chemical Communications, 47 (29). pp. 8262-8264. ISSN 1359-7345

Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. and O'Connell, M. A. (2011) Immunomodulatory effects of 1,25(OH)(2)D-3 in normal and transformed human lung epithelium. Anticancer Research, 31 (4). p. 25. ISSN 0250-7005

Norton, Rosemary, Sexton, DW, Clark, IM, Wilson, AM, Hughes, DA and O'Connell, MA (2011) Response of lung epithelial cells to inflammatory stimuli following exposure to the active form of vitamin D. Proceedings of the Nutrition Society, 70 (OCE3). ISSN 0029-6651

Robbins, Diane, Newton, Annabella F., Gignoux, Camille, Legeay, Jean-Christophe, Sinclair, Alex, Rejzek, Martin, Laxon, Carly A., Yalamanchili, Sai K., Lewis, William, O'Connell, Maria A. and Stockman, Robert A. (2011) Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway. Chemical Science, 11 (2). pp. 2232-2235. ISSN 2041-6539

Howell, Lesley, Gulam, Rosul, Mueller, Anja, O'Connell, Maria and Searcey, Mark (2010) Design and synthesis of threading intercalators to target DNA. Bioorganic & Medicinal Chemistry Letters, 1 (20). pp. 6956-6959. ISSN 1464-3405

Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. and O'Connell, M. A. (2010) Immunomodulatory effects of vitamin D in the respiratory epithelium. Immunology, 131. p. 140. ISSN 0019-2805

White, H., Norton, R., Rushworth, S. A., Mc Carthy, E. and O'Connell, M. A. (2010) LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha. Immunology, 131. pp. 146-147. ISSN 0019-2805

Howell, Lesley, Howman, Aaron, O'Connell, Maria, Mueller, Anja and Searcey, Mark (2009) Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. Bioorganic & Medicinal Chemistry Letters, 19 (20). pp. 5880-5883. ISSN 1464-3405

Mishra, Gita D, McNaughton, Sarah A, O'Connell, Maria, Prynne, Celia J and Kuh, Diana (2009) Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort. Public Health Nutrition, 12 (02). p. 166. ISSN 1475-2727

Rushworth, SA, Macewan, DJ and O'Connell, MA (2008) Lipopolysaccharide induced expression of NQO1 and HO-1 protects against excessive inflammatory responses. The Journal of Immunology, 181 (10). pp. 6730-6737. ISSN 0022-1767

Atkinson, Sarah H., Rockett, Kirk A., Morgan, Gareth, Bejon, Philip A., Sirugo, Giorgio, O'Connell, Maria, Hanchard, Neil, Kwiatkowski, Dominic P. and Prentice, Andrew M. (2008) Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. Blood, 112 (10). pp. 4276-4283. ISSN 0006-4971

Ogborne, Richard M., Rushworth, Stuart and O'Connell, Maria (2008) Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2. Biochemical and Biophysical Research Communications, 373 (4). pp. 584-588. ISSN 1090-2104

O'Connell, Maria and Rushworth, Stuart (2008) Curcumin: potential for hepatic fibrosis therapy? British Journal of Pharmacology, 153 (3). pp. 403-405. ISSN 1476-5381

Rushworth, Stuart, Macewan, David and O'Connell, Maria (2008) Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. Journal of Immunology, 181. pp. 6730-6737. ISSN 0022-1767

Browning, L. M., Krebs, J. D., Moore, C. S., Mishra, G. D., O'Connell, M. A. and Jebb, S. A. (2007) The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes, Obesity & Metabolism, 9 (1). pp. 70-80. ISSN 1462-8902

Prynne, Celia J., Mishra, Gita D., O'Connell, Maria A., Muniz, Graciela, Laskey, M. Ann, Yan, Liya, Prentice, Ann and Ginty, Fiona (2006) Fruit and vegetable intakes and bone mineral status: a cross-sectional study in 5 age and sex cohorts. American Journal of Clinical Nutrition, 83 (6). pp. 1420-1428. ISSN 0002-9165

Atkinson, Sarah H., Rockett, Kirk, Sirugo, Giorgio, Bejon, Philip A., Fulford, Anthony, O'Connell, Maria A., Bailey, Robin, Kwiatkowski, Dominic P. and Prentice, Andrew M. (2006) Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. PLoS Medicine, 3 (5). ISSN 1549-1277

Jugdaohsingh, R., O'Connell, M. A., Sripanyakorn, S. and Powell, J. J. (2006) Moderate alcohol consumption and increased bone mineral density: potential ethanol and non-ethanol mechanisms. Proceedings of the Nutrition Society, 65 (3). pp. 291-310. ISSN 0029-6651

Rushworth, S. A., Ogborne, R. M., Charalambos, C. A. and O'Connell, M. A. (2006) Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochemical and Biophysical Research Communications, 341 (4). pp. 1007-1016. ISSN 0006-291X

Collinson, Andrew, Moore, Sophie, O'Connell, Maria, Charalambos, Charles and Prentice, Andrew (2005) Developmental changes in leptin as a measure of energy status in human infants in a natural ecologic setting. American Journal of Clinical Nutrition, 81 (2). pp. 488-494. ISSN 0002-9165

Ogborne, R. M., Rushworth, S. A. and O'Connell, M. A. (2005) alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (10). pp. 2100-2105. ISSN 1079-5642

Rushworth, S. A., Chen, X. L., Mackman, N., Ogborne, R. M. and O'Connell, M. A. (2005) Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. Journal of Immunology, 175 (7). pp. 4408-4415. ISSN 0022-1767

Browning, L. M., Jebb, S. A., Mishra, G. D., Cooke, J. H., O'Connell, M. A., Crook, M. A. and Krebs, J. D. (2004) Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women. International Journal of Obesity, 28 (8). pp. 1004-1010. ISSN 0307-0565

Moore, S. E., Falorni, A., Bini, V., Fulford, A. J. C., O'Connell, M. A. and Prentice, A. M. (2004) Ethnic differences in the relationship between fasting leptin and BMI in children. International Journal of Obesity, 28 (1). pp. 17-21. ISSN 0307-0565

Ogborne, R. M., Rushworth, S. A., Charalambos, C. A. and O'Connell, M. A. (2004) Haem oxygenase-1: a target for dietary antioxidants. Biochemical Society Transactions, 32 (6). pp. 1003-1005. ISSN 0300-5127

Rushworth, S. A. and O'Connell, M. A. (2004) Haem oxygenase-1 in inflammation. Biochemical Society Transactions, 32. pp. 1093-1094. ISSN 0300-5127

Biesalski, Hans K., Brummer, Robert J., König, Jürgen, O'Connell, Maria A., Ovesen, Lars, Rechkemmer, Gerhard, Stos, Katarzyna and Thurnham, David I. (2003) Micronutrient deficiencies - Hohenheim Consensus Conference. European Journal of Nutrition, 42 (6). pp. 353-363. ISSN 1436-6207

Reddy, V., Bhattacharjee, G., Hollis, A., Kempf, K., O'Connell, M.A., Guha, M. and Mackman, N. (2003) Dexamethasone enhances LPS induction of tissue factor expression in monocytic cells via a post-transcriptional mechanism. The FASEB Journal, 17 (5). A1327-A1327. ISSN 0892-6638

Moore, S. E., Morgan, G., Collinson, A. C., Swain, J. A., O'Connell, M. A. and Prentice, A. M. (2002) Leptin, malnutrition, and immune response in rural Gambian children. Archives of Disease in Childhood, 87 (3). pp. 192-197. ISSN 0003-9888

Prentice, Andrew M., Moore, Sophie E., Collinson, Andrew C. and O'Connell, Maria A. (2002) Leptin and undernutrition. Nutrition Reviews, 60 (10). S56-S67. ISSN 0029-6643

Goggins, M G, Goh, J, O'Connell, M A, Weir, D G, Kelleher, D and Mahmud, N (2001) Soluble adhesion molecules in inflammatory bowel disease. Irish Journal of Medical Science, 170 (2). pp. 107-111. ISSN 0021-1265

Guha, Mausumee, O'Connell, Maria A., Pawlinski, Rafal, Hollis, Angela, McGovern, Patricia, Yan, Shi-Fang, Stern, David and Mackman, Nigel (2001) Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood, 98 (5). pp. 1429-1439. ISSN 0006-4971

Liu, Ru, O'Connell, Maria, Johnson, Kristen, Pritzker, Kenneth, Mackman, Nigel and Terkeltaub, Robert (2000) Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis & Rheumatism, 43 (5). pp. 1145-1155. ISSN 0004-3591

O'Connell, Maria A., Bennett, Brydon L., Mercurio, Frank, Manning, Anthony M. and Mackman, Nigel (1998) Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. Journal of Biological Chemistry, 273 (46). pp. 30410-30414. ISSN 0021-9258

O'Connell, M A, Kelleher, D, Liskamp, R M, Hall, N, O'Neill, L A and Long, A (1997) TNF-mediated cytotoxicity of L929 cells:role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes. Cytokine, 9 (2). pp. 83-92. ISSN 1043-4666

O'Connell, Maria A., Cleere, Roisin, Long, Aideen, O'Neill, Luke A. J. and Kelleher, Dermot (1995) Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78. Journal of Biological Chemistry, 270 (13). pp. 7399-7404. ISSN 0021-9258

Mahmud, N, O'Connell, M A, Stinson, J, Goggins, M G, Weir, D G and Kelleher, D (1995) Tumour necrosis factor-alpha and microalbuminuria in patients with inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 7 (3). pp. 215-219. ISSN 0954-691X

Mahmud, N, Stinson, J, O'Connell, M A, Mantle, T J, Keeling, P W, Feely, J, Weir, D G and Kelleher, D (1994) Microalbuminuria in inflammatory bowel disease. Gut, 35 (11). pp. 1599-1604. ISSN 0017-5749

O'Connell, Maria, Weir, Donald and Kelleher, Dermot (1994) Tumour necrosis factor and cachexia in chronic inflammatory bowel disease. European Journal of Gastroenterology & Hepatology, 6. pp. 821-829. ISSN 0954-691X

Long, A, O'Connell, M, Liskamp, R M and Kelleher, D (1993) Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line. Immunology, 80 (4). pp. 654-657. ISSN 0019-2805

Fan, X J, Chua, A, O'Connell, M A, Kelleher, D and Keeling, P W (1993) Interferon-gamma and tumour necrosis factor production in patients with Helicobacter pylori infection. Irish Journal of Medical Science, 162 (10). pp. 408-411. ISSN 0021-1265

Book Section

Norton, R, Sexton, DW, Clark, IM, Wilson, AM, Hughes, DA and O'Connell, MA (2010) Immunomodulatory effects of vitamin D in the respiratory epithelium. In: Immunology. UNSPECIFIED, p. 140.

White, H, Norton, R, Rushworth, SA, Mc Carthy, E and O'Connell, MA (2010) LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha. In: Immunity. UNSPECIFIED, pp. 146-147.

This list was generated on Fri Dec 3 03:46:32 2021 GMT.