Haem oxygenase-1: a target for dietary antioxidants

Ogborne, R. M., Rushworth, S. A., Charalambos, C. A. and O'Connell, M. A. (2004) Haem oxygenase-1: a target for dietary antioxidants. Biochemical Society Transactions, 32 (6). pp. 1003-1005. ISSN 0300-5127

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Abstract

HO-1 (haem oxygenase-1) is a stress-response enzyme involved in the catabolism of haem. in animal models, it plays a key protective role in vascular disease. HO-1 has anti-inflammatory effects in macrophages and is induced by a range of stimuli, including antioxidants, in various cell types. As dietary antioxidants are considered to be beneficial in vascular disease, their protective effects may occur through induction of HO-1. Emerging evidence suggests that a range of dietary and other naturally occurring antioxidants stimulate HO-1 expression in various cell types, although regulation by these compounds has not been investigated in detail. These studies suggest that HO-1 may be a target for dietary therapy in vascular disease.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Rachel Smith
Date Deposited: 06 Jun 2011 12:11
Last Modified: 21 Apr 2020 20:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/31784
DOI: 10.1042/BST0321003

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