Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

Robbins, Diane, Newton, Annabella F., Gignoux, Camille, Legeay, Jean-Christophe, Sinclair, Alex, Rejzek, Martin, Laxon, Carly A., Yalamanchili, Sai K., Lewis, William, O'Connell, Maria A. and Stockman, Robert A. (2011) Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway. Chemical Science, 11 (2). pp. 2232-2235. ISSN 2041-6539

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Abstract

Tying the knot! The marriage of two-directional synthesis and tandem reactions allows access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional synthesis yields a symmetrical linear “rope-like” keto-dienoate which is then subjected to twelve separate tandem reactions to “tie the rope in knots” thus creating twelve diverse natural product-like scaffolds containing useful functionality for further elaboration.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
UEA Research Groups:	Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Depositing User:	Users 2731 not found.
Date Deposited:	23 Aug 2011 12:43
Last Modified:	28 Mar 2025 02:53
URI:	https://ueaeprints.uea.ac.uk/id/eprint/34588
DOI:	10.1039/C1SC00371B

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