Ferracyclic carbonyl complexes as anti-inflammatory agents

Wright, Mark, Wooldridge, Tyler, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Wright, Joseph ORCID: https://orcid.org/0000-0001-9603-1001 (2020) Ferracyclic carbonyl complexes as anti-inflammatory agents. Chemical Communications, 56 (31). pp. 4300-4303. ISSN 1359-7345

[thumbnail of Fe-CO-release-CC-submission - Copy]
Preview
PDF (Fe-CO-release-CC-submission - Copy) - Accepted Version
Download (512kB) | Preview

Abstract

Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 12 Mar 2020 10:56
Last Modified: 24 Sep 2022 05:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/74481
DOI: 10.1039/D0CC01449D

Actions (login required)

View Item View Item