Ferracyclic carbonyl complexes as anti-inflammatory agents

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Wright, Mark, Wooldridge, Tyler, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Wright, Joseph ORCID: https://orcid.org/0000-0001-9603-1001 (2020) Ferracyclic carbonyl complexes as anti-inflammatory agents. Chemical Communications, 56 (31). pp. 4300-4303. ISSN 1359-7345

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Abstract

Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Chemistry Faculty of Science > School of Pharmacy
UEA Research Groups:	Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Science > Research Groups > Chemistry of Light and Energy Faculty of Science > Research Groups > Energy Materials Laboratory
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	12 Mar 2020 10:56
Last Modified:	22 Oct 2022 05:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/74481
DOI:	10.1039/D0CC01449D

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