Tools
Tools
Angsusing, Jaenjira, Singh, Sudarshan, Samee, Weerasak, Tadtong, Sarin, Stokes, Leanne 
ORCID: https://orcid.org/0000-0003-4013-6781, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Bielecka, Hanna, Toolmal, Nopparut, Mangmool, Supachoke and Chittasupho, Chuda
(2024)
Anti-inflammatory activities of Yataprasen Thai traditional formulary and its active compounds, beta-amyrin and stigmasterol, in RAW264.7 and THP-1 cells.
Pharmaceuticals, 17 (8).
ISSN 1424-8247
Preview |
PDF (pharmaceuticals-17-01018)
- Published Version
Available under License Creative Commons Attribution. Download (11MB) | Preview |
Abstract
Yataprasen (YTPS) remedy formulary, a national Thai traditional medicine formulary, comprises 13 herbal plants. It has been extensively prescribed to relieve osteoarthritis and musculoskeletal pain in the Thai traditional medicine healthcare system. The aim of this study was to investigate the antioxidant and anti-inflammatory properties of the bioactive compounds (β-amyrin and stigmasterol) of YTPS remedy formulary ethanolic extract, along with its composition. The YTPS formulary extract contains 70.30 nM of β-amyrin and 605.76 nM of stigmasterol. The YTPS formulary extract exhibited ABTS and DPPH free radical scavenging activity, with IC50 values of 144.50 ± 2.82 and 31.85 ± 0.18 µg/mL, respectively. The ethanolic extract of YTPS at a concentration of 1000 µg/mL showed a significant (p < 0.01) anti-inflammatory effect, mainly by reducing IL-6 and TNF-α release in response to LPS. NO production was prominently lowered by 50% at 24.76 ± 1.48 µg/mL, 55.52 ± 24.40 µM, and more than 570 µM of YTPS formulary extract, β-amyrin, and stigmasterol, respectively. Major components of YTPS, β-amyrin, and stigmasterol exerted significant anti-inflammatory effects by inhibiting LPS-induced IL-1β, IL-6, TNF-α secretion in THP-1 cells. Our findings suggest that the ethanolic extract from YTPS holds promise as an alternative topical treatment for osteoarthritis and inflammatory disorders, potentially with fewer side effects than non-steroidal anti-inflammatory medications (NSAIDs).
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: Data are contained within the article and Supplementary Materials. |
| Uncontrolled Keywords: | thai traditional medicine formulary,anti-inflammatory activity,antioxidant,natural products,molecular medicine,pharmaceutical science,drug discovery ,/dk/atira/pure/subjectarea/asjc/1300/1313 |
| Faculty \ School: | Faculty of Science > School of Chemistry, Pharmacy and Pharmacology Faculty of Science |
| UEA Research Groups: | Faculty of Science > Research Groups > Molecular and Tissue Pharmacology |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 12 Sep 2024 15:31 |
| Last Modified: | 10 Oct 2024 00:01 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/96748 |
| DOI: | 10.3390/ph17081018 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |