Haem oxygenase-1 in inflammation

Rushworth, S. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2004) Haem oxygenase-1 in inflammation. Biochemical Society Transactions, 32 (6). pp. 1093-1094. ISSN 0300-5127

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HO-1 (haem oxygenase-1) is a stress-inducible enzyme that plays a protective role in inflammation. Pro-inflammatory mediators, including lipopolysaccharide and cytokines, induce HO-1 expression. The 5'-flanking region of the HO-1 gene contains binding sites for the transcription factors that regulate inflammation, including nuclear factor-kappaB and activator protein 1. However, these do not appear to mediate lipopolysaccharide-induced HO-1 gene expression. in response to haem and antioxidants, murine HO-1 is regulated by the transcription factor Nrf2 (NF-E2-related factor 2). This transcription factor may also be important in the regulation of HO-1 by pro-inflammatory stimuli.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017)
Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Science > Research Groups > Molecular and Tissue Pharmacology
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: Rachel Smith
Date Deposited: 06 Jun 2011 12:27
Last Modified: 26 Oct 2023 01:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/31785
DOI: 10.1042/BST0321093

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