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Rushworth, S. A. and O'Connell, M. A. 
ORCID: https://orcid.org/0000-0002-0267-0951
(2004)
Haem oxygenase-1 in inflammation.
Biochemical Society Transactions, 32 (6).
pp. 1093-1094.
ISSN 0300-5127
Abstract
HO-1 (haem oxygenase-1) is a stress-inducible enzyme that plays a protective role in inflammation. Pro-inflammatory mediators, including lipopolysaccharide and cytokines, induce HO-1 expression. The 5'-flanking region of the HO-1 gene contains binding sites for the transcription factors that regulate inflammation, including nuclear factor-kappaB and activator protein 1. However, these do not appear to mediate lipopolysaccharide-induced HO-1 gene expression. in response to haem and antioxidants, murine HO-1 is regulated by the transcription factor Nrf2 (NF-E2-related factor 2). This transcription factor may also be important in the regulation of HO-1 by pro-inflammatory stimuli.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Science > Research Groups > Molecular and Tissue Pharmacology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Rachel Smith |
| Date Deposited: | 06 Jun 2011 12:27 |
| Last Modified: | 24 Sep 2024 10:06 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/31785 |
| DOI: | 10.1042/BST0321093 |
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