Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

Liu, Ru, O'Connell, Maria, Johnson, Kristen, Pritzker, Kenneth, Mackman, Nigel and Terkeltaub, Robert (2000) Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis & Rheumatism, 43 (5). pp. 1145-1155. ISSN 0004-3591

Full text not available from this repository. (Request a copy)

Abstract

Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.

Item Type: Article
Uncontrolled Keywords: calcium pyrophosphate,humans,interleukin-8,mitogen-activated protein kinase 1,mitogen-activated protein kinase 3,mitogen-activated protein kinases,monocytes,nf-kappa b,promoter regions, genetic,rna, messenger,signal transduction,transcription factor ap-1,uric acid
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 11 Jun 2014 13:04
Last Modified: 21 Apr 2020 22:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/48270
DOI: 10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T

Actions (login required)

View Item View Item