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Liu, Ru, O'Connell, Maria 
ORCID: https://orcid.org/0000-0002-0267-0951, Johnson, Kristen, Pritzker, Kenneth, Mackman, Nigel and Terkeltaub, Robert
(2000)
Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells.
Arthritis & Rheumatism, 43 (5).
pp. 1145-1155.
ISSN 0004-3591
Abstract
Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | calcium pyrophosphate,humans,interleukin-8,mitogen-activated protein kinase 1,mitogen-activated protein kinase 3,mitogen-activated protein kinases,monocytes,nf-kappa b,promoter regions, genetic,rna, messenger,signal transduction,transcription factor ap-1,uric acid |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology |
| Depositing User: | Pure Connector |
| Date Deposited: | 11 Jun 2014 13:04 |
| Last Modified: | 25 Sep 2024 11:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/48270 |
| DOI: | 10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T |
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