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ToolsLiu, Ru, O'Connell, Maria, Johnson, Kristen, Pritzker, Kenneth, Mackman, Nigel and Terkeltaub, Robert (2000) Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis & Rheumatism, 43 (5). pp. 1145-1155. ISSN 0004-3591
Full text not available from this repository.Abstract
Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | calcium pyrophosphate,humans,interleukin-8,mitogen-activated protein kinase 1,mitogen-activated protein kinase 3,mitogen-activated protein kinases,monocytes,nf-kappa b,promoter regions, genetic,rna, messenger,signal transduction,transcription factor ap-1,uric acid |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Cell Biology (former - to 2017) Faculty of Science > Research Groups > Molecular and Tissue Pharmacology |
| Depositing User: | Pure Connector |
| Date Deposited: | 11 Jun 2014 13:04 |
| Last Modified: | 06 Feb 2025 04:56 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/48270 |
| DOI: | 10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T |
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