Items where Author is "Bowles, Kristian"

Article

Fowler-Shorten, Dominic J., Maynard, Rebecca S., Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and Hellmich, Charlotte (2024) Acute myeloid leukemia driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias. Haematologica, 109 (5). pp. 1576-1581. ISSN 0390-6078

Wojtowicz, Edyta E., Mistry, Jayna J., Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W., Kettyle, Laura M., Grasso, Francesca, Lord, Allegra M., Wright, David J., Etherington, Graham J., Woll, Petter S., Belderbos, Mirjam E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Nerlov, Claus, Haerty, Wilfried ORCID: https://orcid.org/0000-0003-0111-191X, Bystrykh, Leonid V., Jacobsen, Sten Eirik W., Rushworth, Stuart A. and Macaulay, Iain C. (2023) Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion. Genome Biology, 24. ISSN 1474-760X

Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta E., Hampton, Katherine, Maynard, Rebecca, De Silva, Ravindu ORCID: https://orcid.org/0009-0003-5184-5978, Fowler-Shorten, Dominic J., Mistry, Jayna J., Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression. Blood, 141 (25). 3065–3077. ISSN 0006-4971

Hellmich, Charlotte, Wojtowicz, Edyta, Moore, Jamie A., Mistry, Jayna J., Jibril, Aisha, Johnson, Benjamin B., Smith, James G.W. ORCID: https://orcid.org/0000-0003-0427-8678, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors. Blood Advances, 7 (2). pp. 256-268. ISSN 2473-9529

Mistry, Jayna J., Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis. Experimental Hematology, 117. pp. 1-8. ISSN 0301-472X

Kumar, Prakrit R., Saad, Mona, Hellmich, Charlotte, Mistry, Jayna J., Moore, Jamie A., Conway, Shannon, Morris, Christopher J. ORCID: https://orcid.org/0000-0002-7703-4474, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Moncrieff, Marc D. and Rushworth, Stuart A. (2022) PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma. British Journal of Cancer, 127. 69–78. ISSN 0007-0920

Moore, Jamie A., Mistry, Jayna J., Hellmich, Charlotte, Horton, Rebecca H., Wojtowicz, Edyta E., Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2022) LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation. Journal of Clinical Investigation, 132 (5). ISSN 0021-9738

Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2021) Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection. Nature Communications, 12 (1). ISSN 2041-1723

Lamprinaki, Dimitra, Garcia-Vello, Pilar, Marchetti, Roberta, Hellmich, Charlotte, McCord, Kelli A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Macauley, Matthew S., Silipo, Alba, De Castro, Cristina, Crocker, Paul R. and Juge, Nathalie (2021) Siglec-7 mediates immunomodulation by colorectal cancer-associated Fusobacterium nucleatum ssp. animalis. Frontiers in Immunology, 12. ISSN 1664-3224

Mistry, Jayna J, Hellmich, Charlotte, Lambert, Amelia, Moore, Jamie A, Jibril, Aisha, Collins, Angela, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2021) Venetoclax and Daratumumab combination treatment demonstrates pre-clinical efficacy in mouse models of Acute Myeloid Leukemia. Biomarker Research, 9 (1). ISSN 2050-7771

Shah, Nimish, Eyre, Toby A., Tucker, David, Kassam, Shireen, Parmar, Jasvir, Featherstone, Carrie, Andrews, Peter, Asgari, Elham, Chaganti, Sridhar, Menne, Tobias F., Fox, Christopher P., Pettit, Stephen, Suddle, Abid and Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and The Haemato‐Oncology Task Force of the British Society for Haematology, British Transplantation Society (2021) Front-line management of post-transplantation lymphoproliferative disorder in adult solid organ recipient patients — A British Society for Haematology Guideline. British Journal of Haematology, 193 (4). pp. 727-740. ISSN 0007-1048

Teresa Borrello, Maria, Benelkebir, Hanae, Lee, Adam, Hin Tam, Chak, Shafat, Manar, Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Douglas, Leon, Duriez, Patrick J., Bailey, Sarah, Crabb, Simon J., Packham, Graham and Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999 (2021) Synthesis of carboxamide-containing tranylcypromine analogues as LSD1 (KDM1A) inhibitors targeting acute myeloid leukemia. ChemMedChem, 16 (8). pp. 1316-1324. ISSN 1860-7179

Mistry, Jayna J., Moore, Jamie A., Kumar, Prakritt, Marlein, Christopher R., Hellmich, Charlotte, Pillinger, Genevra, Jibril, Aisha, Di Palma, Federica, Collins, Angela, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2021) Daratumumab inhibits acute myeloid leukemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells. Haematologica, 106 (2). pp. 589-592. ISSN 0390-6078

Kumar, Prakrit R., Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and Moncrieff, Marc D. (2021) Mitochondrial oxidative phosphorylation in cutaneous melanoma. British Journal of Cancer, 124 (1). pp. 115-123. ISSN 0007-0920

Brodie, James, Zhou, Sean, Makkuni, Damodar, Beadsmoore, Clare, Mukhtyar, Chetan ORCID: https://orcid.org/0000-0002-9771-6667, Saada, Janak, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Beigi, Bijan and Burton, Ben J. L. (2020) Erdheim-Chester Disease: Two cases from an ophthalmic perspective. American Journal of Ophthalmology Case Reports, 20. ISSN 2451-9936

Hellmich, Charlotte, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2020) ARQ531: The therapy that targets multiple pathways in acute myeloid leukemia. Haematologica, 105 (10). pp. 2350-2352. ISSN 0390-6078

Gamble, David T., Buono, Romain, Mamas, Mamas A., Leslie, Stephen, Bettencourt-Silva, Joao H., Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526, Metcalf, Anthony K., Potter, John and Myint, Phyo (2020) Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter? European Journal of Preventive Cardiology, 27 (7). pp. 729-737. ISSN 2047-4873

Hellmich, Charlotte, Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2020) Bone marrow senescence and the microenvironment of hematological malignancies. Frontiers in Oncology, 10. ISSN 2234-943X

Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W. ORCID: https://orcid.org/0000-0003-0427-8678, Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J. ORCID: https://orcid.org/0000-0002-7703-4474, Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2019) ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection. Proceedings of the National Academy of Sciences of the United States of America, 116 (49). pp. 24610-24619. ISSN 1091-6490

Vart, Priya, Barlas, Raphae S, Bettencourt-Silva, Joao H, Metcalf, Anthony K, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F and Myint, Phyo K (2019) Estimated glomerular filtration rate and risk of poor outcomes after stroke. European Journal of Neurology, 26 (12). pp. 1455-1463. ISSN 1351-5101

Gamble, David T., Buono, Romain, Mamas, Mamas A., Leslie, Stephen, Bettencourt-Silva, Joao H., Clark, Allan, Bowles, Kristian, Metcalf, Anthony K., Potter, John and Myint, Phyo (2019) Does prior antithrombotic therapy influence recurrence and bleeding risk in stroke patients with atrial fibrillation or atrial flutter? European Journal of Preventive Cardiology. ISSN 2047-4873 (In Press)

Bhatti, Maria, Ayton, Sarah, Michail, Olga, Gollop, Nicholas D., Ryding, Alisdair, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526, Geisler, Tobias and Flather, Marcus (2019) Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction. Thrombosis Research, 179. pp. 64-68. ISSN 0049-3848

Marlein, Christopher, Piddock, Rachel E., Mistry, Jayna J., Zaitseva, Lyubov, Hellmich, Charlotte, Horton, Rebecca H., Zhou, Zhigang, Auger, Martin J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2019) CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma. Cancer Research, 79 (9). pp. 2285-2297. ISSN 0008-5472

Abdul-Aziz, Amina M, Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R, Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E, Shafat, Manar S, Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J, Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2019) Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment. Blood, 133 (5). pp. 446-456. ISSN 0006-4971

Teh, W. H., Smith, C. J., Barlas, R. S., Wood, A. D., Bettencourt-Silva, J. H., Clark, A. B. ORCID: https://orcid.org/0000-0003-2965-8941, Metcalf, A. K., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526, Potter, J. F. and Myint, P. K. (2018) Impact of stroke‐associated pneumonia on mortality, length of hospitalization, and functional outcome. Acta Neurologica Scandinavica, 138 (4). pp. 293-300. ISSN 0001-6314

Barlas, Raphae S., Loke, Yoon K., Mamas, Mamas A., Bettencourt-Silva, Joao H., Ford, Isobel, Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Metcalf, Anthony K., Potter, John F. and Myint, Phyo K. (2018) Effect of antiplatelet therapy (aspirin +dipyridamole versus clopidogrel) on mortality outcome in ischemic stroke. The American Journal of Cardiology, 122 (6). pp. 1085-1090. ISSN 0002-9149

Vart, Priya, Bettencourt-Silva, Joao H, Metcalf, Anthony K, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F and Myint, Phyo K (2018) Low estimated glomerular filtration rate and pneumonia in stroke patients: findings from a prospective stroke registry in the East of England. Clinical Epidemiology, 2018 (10). pp. 887-896. ISSN 1179-1349

Bhatti, M., Michail, O., Ayton, S., Gollop, N. D., Ryding, A., Rushworth, S., Bowles, K. ORCID: https://orcid.org/0000-0003-1334-4526 and Flather, M. (2018) Potential for Bruton's tyrosine kinase inhibitors as additional antiplatelet agents in acute coronary syndromes. European Heart Journal, 39 (Supplement 1). p. 747. ISSN 0195-668X

Marlein, Christopher, Zaitseva, Lyubov, Piddock, Rachel, Raso-Barnett, Livia, Scott, Michael, Ingham, Christopher, Collins, Angela, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2018) PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts. Leukemia, 32. 2073–2077. ISSN 0887-6924

Bhatti, Maria, Ayton, Sarah, Michail, Olga, Gollop, Nicholas D., Ryding, Alisdair, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Flather, Marcus (2018) The effect of BTK inhibitors on platelet aggregation in acute coronary syndromes. Heart, 104. A7-A8. ISSN 1355-6037

Piddock, Rachel E., Marlein, Christopher R., Abdul-Aziz, Amina, Shafat, Manar S., Auger, Martin J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2018) Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC. Journal of Hematology & Oncology, 11. ISSN 1756-8722

Piddock, Rachel E., Marlein, Christopher R., Abdul-Aziz, Amina, Shafat, Manar S., Auger, Martin J., Bowles, Kristian M. and Rushworth, Stuart A. (2018) Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC. Journal of Hematology & Oncology, 11. ISSN 1756-8722

Eyre, Toby A., Osborne, Wendy L., Gallop-Evans, Eve, Ardeshna, Kirit M., Kassam, Shireen, Sadullah, Shalal, Sidra, Gamal, Culligan, Dominic, Arumainathan, Arvind, Shankara, Paneesha, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Eyre, David W., Peng, Ying Y., Pettengell, Ruth, Bloor, Adrian, Vandenberghe, Elisabeth and Collins, Graham P. (2018) Results of a multicentre UK-wide compassionate use programme evaluating the efficacy of idelalisib monotherapy in relapsed, refractory follicular lymphoma. British Journal of Haematology, 181 (4). pp. 555-559. ISSN 0007-1048

Foster, Emma J., Barlas, Raphae S., Bettencourt-Silva, Joao H., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Metcalf, Anthony K., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F. and Myint, Phyo K. (2018) Long-term factors associated with falls and fractures poststroke. Frontiers in Neurology, 9. ISSN 1664-2295

McCall, Stephen J., Alanazi, Turkiah A., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Musgrave, Stanley D., Bettencourt-Silva, Joao H., Bachmann, Max O. ORCID: https://orcid.org/0000-0003-1770-3506, Metcalf, Anthony K., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Mamas, Mamas A., Potter, John F. and Myint, Phyo K. (2018) Hyperglycaemia and the SOAR stroke score in predicting mortality. Diabetes & Vascular Disease Research, 15 (2). pp. 114-121. ISSN 1479-1641

Sun, Yu, Abdul Aziz, Amina, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2018) High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma. Cancer Letters, 412. pp. 37-45. ISSN 0304-3835

Abdul-Aziz, Amina M., Shafat, Manar S., Sun, Yu, Marlein, Christopher R., Piddock, Rachel E., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Zhou, Zhigang, Collins, Angela, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2018) HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene, 37. 2676–2686. ISSN 0950-9232

Nimmagadda, S C, Frey, S, Edelmann, B, Hellmich, C, Zaitseva, L, König, G M, Kostenis, E, Bowles, K M ORCID: https://orcid.org/0000-0003-1334-4526 and Fischer, T (2018) Bruton’s tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia. Leukemia, 32. 846–849. ISSN 0887-6924

Barlas, Raphae S., McCall, Stephen J., Bettencourt-Silva, Joao H., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Metcalf, Anthony K., Mamas, Mamas A, Potter, John F. and Myint, Phyo K. (2017) Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register. Journal of the Neurological Sciences, 383. pp. 26-30. ISSN 0022-510X

Griffin, Jessica C., Sadullah, Shalal, Igali, Lazlo, Shah, Nimish K., Wimperis, Jennifer Z. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2017) Nodular lymphocyte predominant Hodgkin lymphoma: A real-world case series of consecutive patients treated by a single multidisciplinary team in the east of England from 1999 to 2015. Clinical Lymphoma, Myeloma and Leukemia, 17 (12). e75-e78. ISSN 2152-2650

Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064, Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts. Blood, 130 (14). pp. 1649-1660. ISSN 0006-4971

Foster, Emma J., Barlas, Raphae S., Wood, Adrian D, Bettencourt-Silva, Joao H, Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Metcalf, Anthony K., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F. and Myint, Phyo K. (2017) A history of falls is associated with a significant increase in acute mortality in women after stroke. Journal of Clinical Neurology, 13 (4). pp. 411-421. ISSN 1738-6586

Shafat, Manar S., Gnaneswaran, Bruno, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) The bone marrow microenvironment – Home of the leukemic blasts. Blood Reviews, 31 (5). 277–286. ISSN 0268-960X

Curtain, James P., Yu, Man, Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Gollop, Nicholas D., Bettencourt-Silva, Joao H., Metcalf, Anthony Kneale, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Flather, Marcus D., Potter, John F. and Myint, Phyo Kyaw (2017) Determinants of length of stay following total anterior circulatory stroke. BMC Geriatrics, 2 (3). ISSN 1471-2318

Chandran, Sujay, Watkins, Johnathan, Abdul‐Aziz, Amina, Shafat, Manar, Calvert, Patrick A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Flather, Marcus D., Rushworth, Stuart A. and Ryding, Alisdair D. (2017) Inflammatory differences in plaque erosion and rupture in patients with ST-segment elevation myocardial infarction. Journal of the American Heart Association, 6 (5). ISSN 2047-9980

Adekunle-Olarinde, Iyabo R., McCall, Stephen J., Barlas, Raphae S., Wood, Adrian D., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Bettencourt-Silva, Joao H., Metcalf, Anthony K., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Soiza, Roy L., Potter, John F. and Myint, Phyo K. (2017) Addition of sodium criterion to SOAR stroke score. Acta Neurologica Scandinavica, 135 (5). 553–559. ISSN 0001-6314

Piddock, Rachel E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) The role of PI3K isoforms in regulating bone marrow microenvironment signaling focusing on acute myeloid leukemia and multiple myeloma. Cancers, 9 (4). ISSN 2072-6694

Piddock, R E, Loughran, N, Marlein, C R, Robinson, S D ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, D R ORCID: https://orcid.org/0000-0002-3292-2064, Yu, S, Pillinger, G E, Zhou, Z, Zaitseva, L, Auger, M J, Rushworth, S A and Bowles, K M ORCID: https://orcid.org/0000-0003-1334-4526 (2017) PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment. Blood Cancer Journal, 7 (3). ISSN 2044-5385

Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment. Blood, 129 (10). pp. 1320-1332. ISSN 0006-4971

Abdul-Aziz, Amina, Shafat, Manar, Mehta, Tarang, Di Palma, Federica, Lawes, Matthew, Rushworth, Stuart A. and Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 (2017) MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia. Cancer Research, 77 (2). pp. 303-311. ISSN 0008-5472

Wood, Adrian D, Gollop, Nicholas D, Bettencourt-Silva, Joao H, Clark, Allan B ORCID: https://orcid.org/0000-0003-2965-8941, Metcalf, Anthony K, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Flather, Marcus D, Potter, John F and Myint, Phyo Kyaw (2016) A 6-point TACS score predicts in-hospital mortality following total anterior circulation stroke. Journal of Clinical Neurology, 12 (4). pp. 407-413. ISSN 1738-6586

Wittmann, Alexandra, Lamprinaki, Dimitra, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Katzenellenbogen, Ewa, Knirel, Yuriy A., Whitfield, Chris, Nishimura, Takashi, Matsumoto, Naoki, Yamamoto, Kazuo, Iwakura, Yoichiro, Saijo, Shinobu and Kawasaki, Norihito (2016) Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells. Journal of Biological Chemistry, 291 (34). pp. 17629-17638. ISSN 0021-9258

Barlas, Raphae S., Honney, Katie, Loke, Yoon K., McCall, Stephen J., Bettencourt-Silva, Joao H., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Metcalf, Anthony K., Mamas, Mamas A., Potter, John F. and Myint, Phyo K. (2016) Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review and meta-analysis. Journal of the American Heart Association, 5 (8). ISSN 2047-9980

Pillinger, Genevra, Loughran, Niamh V., Piddock, Rachel E., Shafat, Manar S., Zaitseva, Lyubov, Abdul-Aziz, Amina, Lawes, Matthew J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2016) Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection. Oncotarget, 7 (26). pp. 39784-39795. ISSN 1949-2553

Soiza, Roy L, Cumming, Kirsten, Clark, Allan B ORCID: https://orcid.org/0000-0003-2965-8941, Bettencourt-Silva, Joao H, Metcalfe, Anthony K, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F and Myint, Phyo (2015) Hyponatremia predicts mortality after stroke. International Journal of Stroke, 10 (A100). pp. 50-55. ISSN 1747-4930

Pillinger, Genevra, Abdul-Aziz, Amina, Zaitseva, Lyubov, Lawes, Matt, MacEwan, David, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2015) Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia. Scientific Reports, 5. ISSN 2045-2322

Murray, Megan Y., Zaitseva, Lyubov, Auger, Martin J., Craig, Jenny I.O., MacEwan, David, Rushworth, Stuart A. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma. Cell Cycle, 14 (14). pp. 2367-2375. ISSN 1538-4101

Rushworth, Stuart A., Pillinger, Genevra, Abdul-Aziz, Amina, Piddock, Rachel, Shafat, Manar S., Murray, Megan Y., Zaitseva, Lyubov, Lawes, Matthew J., MacEwan, David J. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells. The Lancet Haematology, 2 (5). e204-e211.

Shah, N. M., Zaitseva, L., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526, MacEwan, D. J. and Rushworth, S. A. (2015) NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. Cell Death and Differentiation, 22. pp. 654-664. ISSN 1350-9047

Mannu, Gurdeep S., Macartney, Alistair, Lambert, Jonathan R. A., Bettencourt-silva, Joao H., Lawn, Mark, Lyall, Hamish, Metcalf, Anthony Kneale, Potter, John F., Wood, John, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Baglin, Trevor, Myint, Phyo Kyaw and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack. European Journal of Haematology, 94 (2). 138–144. ISSN 0902-4441

Zaitseva, Lyubov, Murray, Megan Y, Shafat, Manar S., Lawes, Matthew J, MacEwan, David J, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2014) Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML. Oncotarget, 5 (20). pp. 9930-9938. ISSN 1949-2553

Murray, Megan, Auger, Martin and Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 (2014) Overcoming bortezomib resistance in multiple myeloma. Biochemical Society Transactions, 42 (4). pp. 804-808. ISSN 0300-5127

Seguna, Ryan, Maw, Kyaw Z, Lyall, Hamish D and Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 (2014) “Haemorrhagic disease of the newborn” 89 years later than expected: vitamin K deficiency bleeding. The Lancet, 384 (9942). p. 556. ISSN 0140-6736

Rushworth, Stuart A., Murray, Megan Y., Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2014) Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia. Blood, 123 (8). pp. 1229-1238. ISSN 0006-4971

Rushworth, Stuart A., MacEwan, David J. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2013) Ibrutinib in relapsed chronic lymphocytic leukemia. New England Journal of Medicine, 369 (13). pp. 1277-1278. ISSN 1533-4406

Shah, Niraj M., Rushworth, Stuart, Murray, Megan A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2013) Understanding the role of NRF2-regulated miRNAs in human malignancies. Oncotarget, 4 (8). pp. 1130-1142. ISSN 1949-2553

Murray, Megan Y., Rushworth, Stuart A., Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2013) Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. Cell Cycle, 12 (13). pp. 2144-2153.

Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Barrera, Lawrence N., Murray, Megan Y., Zaitseva, Lyubov and MacEwan, David J. (2013) BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. Cellular Signalling, 25 (1). pp. 106-112.

MacEwan, David, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2013) Emerging therapy targeting tyrosine-protein kinase BTK: potential for ibrutinib and other BTK inhibitors. Drugs of the Future, 38 (8). pp. 569-573. ISSN 2013-0368

Rushworth, Stuart A., Zaitseva, Lyubov, Murray, Megan Y., Shah, Niraj M., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2012) The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance. Blood, 120 (26). pp. 5188-5198. ISSN 0006-4971

Barrera, Lawrence N., Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2012) Bortezomib induces heme oxygenase-1 expression in multiple myeloma. Cell Cycle, 11 (12). pp. 2248-2252. ISSN 1538-4101

Heasman, S.-A., Zaitseva, L., Bowles, K. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, S. A. and MacEwan, D. J. (2011) Heme oxygenase-1 protects acute myeloid leukaemia cells from front line chemotherapeutic drugs. Basic & Clinical Pharmacology & Toxicology, 109. p. 96. ISSN 1742-7843

Rushworth, S. A., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, D. J. (2011) Elevated NRF2 levels in acute myeloid leukaemia reduces sensitivity towards proteasome inhibitors. Basic & Clinical Pharmacology & Toxicology, 109. p. 31. ISSN 1742-7843

Heasman, Sally-Anne, Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and MacEwan, David J. (2011) Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1. Oncotarget, 2 (9). pp. 658-668.

Gibbs, Simon D J, Williams, Stuart M, Tyler, Xenia, Pearson, John, Bennie, Mary Jane and Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 (2011) You can't have your cake and eat it too. Gut, 60 (6). 852, 860. ISSN 0017-5749

Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2011) High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors. Cancer Research, 71 (5). pp. 1999-2009. ISSN 0008-5472

Rushworth, Stuart A, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Raninga, Prahlad and MacEwan, David J (2010) NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. Cancer Research, 70 (7). pp. 2973-2983. ISSN 0008-5472

Rushworth, Stuart A., Zaitseva, Lyubov, Langa Marcano, Susana, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2010) FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism. Oncotarget, 1 (5). pp. 359-366. ISSN 1949-2553

Pozo, Anna L, Godfrey, Edmund M and Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 (2009) Splenomegaly:investigation, diagnosis and management. Blood Reviews, 23 (3). pp. 105-11. ISSN 1532-1681

Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Warner, Brian A and Baglin, Trevor P (2006) Platelet mass has prognostic value in patients with myelodysplastic syndromes. British Journal of Haematology, 135 (2). pp. 198-200. ISSN 0007-1048

Taylor, Anna L., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Callaghan, Christopher J., Wimperis, Jenny Z., Grant, John W., Marcus, Robert E. and Bradley, J. Andrew (2006) Anthracycline-based chemotherapy as first-line treatment in adults with malignant posttransplant lymphoproliferative disorder after solid organ transplantation. Transplantation, 82 (3). pp. 375-381. ISSN 0041-1337

Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Bloxham, David M, Perry, David J and Baglin, Trevor P (2006) Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura. British Journal of Haematology, 134 (3). pp. 320-2. ISSN 0007-1048

Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Vallier, Ludovic, Smith, Joseph R, Alexander, Morgan R J and Pedersen, Roger A (2006) HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells. Stem Cells, 24 (5). pp. 1359-1369. ISSN 1066-5099

Conference or Workshop Item

Jibril, Aisha, Hellmich, Charlotte, Moore, Jamie A., Mistry, Jayna, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Willimott, Victoria (2021) Multiple myeloma derived mitochondrial damps induce inflammation in the bone marrow adipose tissue which promotes tumour development. In: UNSPECIFIED.