HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis

Mistry, Jayna J., Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis. Experimental Hematology, 117. pp. 1-8. ISSN 0301-472X

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Metabolism impacts all cellular functions and plays a fundamental role in physiology. Metabolic regulation of hematopoiesis is dynamically regulated under steady-state and stress conditions. It is clear that hematopoietic stem cells (HSCs) impose different energy demands and flexibility during maintenance compared with stressed conditions. However, the cellular and molecular mechanisms underlying metabolic regulation in HSCs remain poorly understood. In this review, we focus on defining the role of fatty acid oxidation (FAO) in HSCs. We first review the existing literature describing FAO in HSCs under steady-state hematopoiesis. Next, we describe the models used to examine HSCs under stress conditions, and, finally, we describe how infection causes a shift toward FAO in HSCs and the impact of using this pathway on emergency hematopoiesis.

Item Type: Article
Uncontrolled Keywords: molecular biology,hematology,genetics,cell biology,cancer research ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 11 Oct 2022 10:31
Last Modified: 15 Jul 2024 01:12
URI: https://ueaeprints.uea.ac.uk/id/eprint/88948
DOI: 10.1016/j.exphem.2022.10.003


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