Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura

Bowles, Kristian M, Bloxham, David M, Perry, David J and Baglin, Trevor P (2006) Discrepancy between impedance and immunofluorescence platelet counting has implications for clinical decision making in patients with idiopathic thrombocytopenia purpura. British Journal of Haematology, 134 (3). pp. 320-2. ISSN 0007-1048

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Abstract

This study investigated whether differences occur between the impedance and immunofluorescence methods for platelet quantification in idiopathic thrombocytopenia purpura (ITP). Immunofluorescence gave a platelet count >50% higher than the impedance test in 9/35 (26%) patients, of which 4/35 (11%) were >100% higher. The clinical severity of thrombocytopenia was changed as a result of the immunofluorescence test in 14/35 (40%) patients. Neither mean platelet volume nor platelet distribution width predicted impedance/immunofluorescence method discrepancy. It is suggested that immunofluorescence platelet counts should be performed on all ITP patients when the implementation of a therapeutic or diagnostic intervention is being considered.

Item Type: Article
Uncontrolled Keywords: blood coagulation,fluorescent antibody technique,humans,patient selection,platelet count,purpura, thrombocytopenic, idiopathic
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 16 Dec 2013 15:12
Last Modified: 24 Jul 2019 19:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/45985
DOI: 10.1111/j.1365-2141.2006.06165.x

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