Splenomegaly:investigation, diagnosis and management

Pozo, Anna L, Godfrey, Edmund M and Bowles, Kristian M (2009) Splenomegaly:investigation, diagnosis and management. Blood Reviews, 23 (3). pp. 105-11. ISSN 1532-1681

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Abstract

Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields. This review examines the aetiology of splenomegaly in the developed world, and describes a logical approach to the patient with splenomegaly. In some patients, extensive radiological and laboratory investigations will fail to yield a diagnosis: these cases of "isolated" splenomegaly are not uncommon and can be particularly challenging to manage. The risks of serious underlying disease must be balanced against the risks of invasive investigations such as splenic biopsy and diagnostic splenectomy. We discuss the options in isolated splenomegaly and their evidence base, and incorporate them into a management strategy to aid the clinician in cases of diagnostic difficulty.

Item Type: Article
Uncontrolled Keywords: biopsy, fine-needle,diagnosis, differential,humans,splenectomy,splenomegaly,tomography, x-ray computed
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 16 Dec 2013 15:12
Last Modified: 21 Apr 2020 22:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/45982
DOI: 10.1016/j.blre.2008.10.001

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