Tools
Tools
Mistry, Jayna J, Hellmich, Charlotte, Lambert, Amelia, Moore, Jamie A, Jibril, Aisha, Collins, Angela, Bowles, Kristian M 
ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A
(2021)
Venetoclax and Daratumumab combination treatment demonstrates pre-clinical efficacy in mouse models of Acute Myeloid Leukemia.
Biomarker Research, 9 (1).
ISSN 2050-7771
Preview |
PDF (Published_Version)
- Accepted Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Acute myeloid leukemia (AML) remains an incurable malignancy despite recent advances in treatment. Recently a number of new therapies have emerged for the treatment of AML which target BCL-2 or the membrane receptor CD38. Here, we show that treatment with Venetoclax and Daratumumab combination resulted in a slower tumor progression and a reduced leukemia growth both in vitro and in vivo. These data provide evidence for clinical evaluation of Venetoclax and Daratumumab combination in the treatment of AML.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | molecular medicine,clinical biochemistry,biochemistry, medical ,/dk/atira/pure/subjectarea/asjc/1300/1313 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 May 2021 00:09 |
| Last Modified: | 25 Oct 2023 01:45 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80047 |
| DOI: | 10.1186/s40364-021-00291-y |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |