Hyperglycaemia and the SOAR stroke score in predicting mortality

McCall, Stephen J., Alanazi, Turkiah A., Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Musgrave, Stanley D., Bettencourt-Silva, Joao H., Bachmann, Max O. ORCID: https://orcid.org/0000-0003-1770-3506, Metcalf, Anthony K., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Mamas, Mamas A., Potter, John F. and Myint, Phyo K. (2018) Hyperglycaemia and the SOAR stroke score in predicting mortality. Diabetes & Vascular Disease Research, 15 (2). pp. 114-121. ISSN 1479-1641

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Background: We assessed the association between admission blood glucose levels and acute stroke mortality and examined whether there was any incremental value of adding glucose status to the validated acute stroke mortality predictor – the SOAR (stroke subtype, Oxford Community Stroke Project classification, age, and pre-stroke modified Rankin) score. Methods: Data from Norfolk and Norwich University Hospital stroke and Transient Ischaemic Attack register (2003–2013) and Anglia Stroke Clinical Network Evaluation Study (2009–2012) were analysed. Multivariable logistic regression analysis assessed the association between admission blood glucose levels with inpatient and 7-day mortality. The prognostic ability of the SOAR score was then compared with the SOAR with glucose score. Results: A total of 5575 acute stroke patients (ischaemic stroke: 89.2%) with mean age (standard deviation) of 76.97 ( ± 11.88 ) years were included. Both borderline hyperglycaemia (7.9–11.0 mmol/L) and hyperglycaemia (>11.0 mmol/L) when compared to normoglycaemia (4.0–7.8 mmol/L) were associated with both 7-day and inpatient mortality after controlling for sex, age, Oxford Community Stroke Project classification and pre-stroke modified Rankin score. Both the SOAR stroke score and SOAR-G score were good predictors of inpatient stroke mortality [area under the curve: 0.82 (95% confidence interval: 0.81–0.84) and 0.83 (95% confidence interval: 0.81–0.84)], respectively. These scores were also good at predicting outcomes in both patients with and without diabetes. Conclusion: High blood glucose levels at admission were associated with worse acute stroke mortality outcomes. The constituents of the SOAR stroke score were good at predicting mortality after stroke.

Item Type: Article
Uncontrolled Keywords: hyperglycaemia,prognostic score,stroke mortality,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 06 Dec 2017 06:07
Last Modified: 22 Oct 2022 03:24
URI: https://ueaeprints.uea.ac.uk/id/eprint/65685
DOI: 10.1177/1479164117743034

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