Effect of antiplatelet therapy (aspirin +dipyridamole versus clopidogrel) on mortality outcome in ischemic stroke

Barlas, Raphae S., Loke, Yoon K., Mamas, Mamas A., Bettencourt-Silva, Joao H., Ford, Isobel, Clark, Allan B. ORCID: https://orcid.org/0000-0003-2965-8941, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Metcalf, Anthony K., Potter, John F. and Myint, Phyo K. (2018) Effect of antiplatelet therapy (aspirin +dipyridamole versus clopidogrel) on mortality outcome in ischemic stroke. The American Journal of Cardiology, 122 (6). pp. 1085-1090. ISSN 0002-9149

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Abstract

The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectively collected data from the Norfolk and Norwich University Hospital Stroke Register (NNUHSR). The sample population consisted of 3,572 participants (mean age 74.96 ± 12.67) with ischemic stroke, who were consecutively admitted between 2003-2015. Patients were placed on one of three antiplatelet regimens at hospital discharge; aspirin monotherapy, aspirin plus dipyridamole and clopidogrel. Clopidogrel and aspirin plus dipyridamole was compared to aspirin. A direct comparison between clopidogrel and aspirin plus dipyridamole was also performed. Outcomes included all-cause mortality and a combined endpoint of all-cause mortality and incidence of major adverse cardiac events (stroke or myocardial infarction). Cox-regression models adjusted for potential confounders at the following time periods after discharge; 0-90 days, 91-365 days and 1-3 years. Aspirin plus dipyridamole was associated with a lower risk of mortality at 0-90 days; HR 0.62 (0.43-0.91). Clopidogrel was associated with a lower risk of mortality at 1-3 years; HR of 0.39 (0.26-0.60). Similar HRs were observed for the the corresponding time points in the composite outcome. In conclusion Patients with non-cardioembolic stroke may gain maximum benefit from aspirin plus dipyridamole initially (≤1 year) with a subsequent switch to clopidogrel, with regard to mortality and MACE outcomes.

Item Type:	Article
Uncontrolled Keywords:	ischemic stroke,secondary prevention,antiplatelets,outcomes
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:	https://www.ajconline.org/article/S0002-...
Depositing User:	LivePure Connector
Date Deposited:	20 Jul 2018 16:31
Last Modified:	19 Oct 2023 02:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/67748
DOI:	10.1016/j.amjcard.2018.05.043

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