Understanding the role of NRF2-regulated miRNAs in human malignancies

Shah, Niraj M., Rushworth, Stuart, Murray, Megan A., Bowles, Kristian M. and MacEwan, David J. (2013) Understanding the role of NRF2-regulated miRNAs in human malignancies. Oncotarget, 4 (8). pp. 1130-1142. ISSN 1949-2553

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Abstract

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a key transcription factor that regulates the expression of over a hundred cytoprotective and antioxidant genes that provide cellular protection from reactive oxygen species. Chemotherapy resistance in several cancers has been linked to dysregulation of the NRF2 signalling pathway, moreover there is growing evidence that NRF2 may contribute to tumorigenesis. MicroRNA (miRNA) are small non-coding RNA sequences that post-transcriptionally regulate mRNA sequences. In cancer pathogenesis, aberrantly expressed miRNAs can act as either tumor suppressor or oncogenic miRNA. Recent evidence has been described that identifies a number of miRNA that can be regulated by NRF2. This review outlines the importance of NRF2 in regulating miRNA, and the functional role this may have in the tumorigenesis of human malignancies and their chemotherapy resistance.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	05 Oct 2013 00:54
Last Modified:	28 Mar 2025 05:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43567
DOI:	10.18632/oncotarget.1181

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